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PMID: 10357855 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.

Microbiology and molecular biology reviews : MMBR ·Vol. 63 ·No. 2 ·1999-06-00 ·Pages 349-404

Pâques F, Haber JE

Abstract

The budding yeast Saccharomyces cerevisiae has been the principal organism used in experiments to examine genetic recombination in eukaryotes. Studies over the past decade have shown that meiotic recombination and probably most mitotic recombination arise from the repair of double-strand breaks (DSBs). There are multiple pathways by which such DSBs can be repaired, including several homologous recombination pathways and still other nonhomologous mechanisms. Our understanding has also been greatly enriched by the characterization of many proteins involved in recombination and by insights that link aspects of DNA repair to chromosome replication. New molecular models of DSB-induced gene conversion are presented. This review encompasses these different aspects of DSB-induced recombination in Saccharomyces and attempts to relate genetic, molecular biological, and biochemical studies of the processes of DNA repair and recombination.

MeSH Terms
Adenosine Triphosphatases Animals DNA Damage/genetics DNA Helicases DNA Repair/genetics,physiology DNA Repair Enzymes DNA Replication/physiology DNA, Fungal/genetics DNA-Binding Proteins/physiology Deoxyribonucleases, Type II Site-Specific/physiology Fungal Proteins/physiology Humans Meiosis Rad52 DNA Repair and Recombination Protein Rec A Recombinases/metabolism Recombination, Genetic/genetics Saccharomyces cerevisiae/genetics Saccharomyces cerevisiae Proteins
Chemicals
DNA, Fungal DNA-Binding Proteins Fungal Proteins RAD52 protein, S cerevisiae RAD55 protein, S cerevisiae Rad52 DNA Repair and Recombination Protein Saccharomyces cerevisiae Proteins Rec A Recombinases SCEI protein, S cerevisiae Deoxyribonucleases, Type II Site-Specific Adenosine Triphosphatases RAD54 protein, S cerevisiae RAD57 protein, S cerevisiae DNA Helicases DNA Repair Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pâques F
Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110, USA.
Haber J E
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.63.2.349-404.1999
Published
1999-06-00
Pages
349-404
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC98970
Subset
IM
External Links
PubMed source DOI: 10.1128/MMBR.63.2.349-404.1999 PMC Full Text View journal details
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