The DNA repair capability of cdc9, the Saccharomyces cerevisiae mutant defective in DNA ligase.

Molecular & general genetics : MGG ·Vol. 170 ·No. 1 ·1979-02-16 ·Pages 89-92

Johnston LH

Abstract

The cell cycle mutant, cdc9, in the yeast Saccharomyces cerevisiae is defective in DNA ligase be deficient in the repair of DNA damaged by methyl methane sulphonate. On the other hand survival of cdc9 after irradiation by gamma-rays is little different from that of the wild-type, even after a period of stress at the restrictive temperature. The mutant cdc9 is not allelic with any known rad or mms mutants.

MeSH Terms

DNA Ligases/genetics DNA Repair Gamma Rays Methyl Methanesulfonate/pharmacology Mutagens Mutation Phenotype Polynucleotide Ligases/genetics Saccharomyces cerevisiae/drug effects,genetics,radiation effects

Chemicals

Mutagens Methyl Methanesulfonate DNA Ligases Polynucleotide Ligases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Johnston L H

References (11)

11 references, click to expand

Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase.
J Mol Biol. 1973 Jul 15;77(4):519-29 PMID: 4353283
Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants.
Genetics. 1973 Jun;74(2):267-86 PMID: 17248617
The relevance of the nuclear division cycle to radiosensitivity in yeast.
Mol Gen Genet. 1978 Jul 4;162(3):277-86 PMID: 355834
DNA ligase mutants of Escherichia coli.
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1580-7 PMID: 4922293
Genetic control of the cell division cycle in yeast. 3. Seven genes controlling nuclear division.
Exp Cell Res. 1971 Aug;67(2):389-401 PMID: 5097524
Properties of a temperature-sensitive, radiation-sensitive mutant of Escherichia coli. II. DNA replication.
Proc Natl Acad Sci U S A. 1969 Dec;64(4):1195-202 PMID: 4916921
Genetics and function of DNA ligase in Escherichia coli.
J Mol Biol. 1973 Jul 15;77(4):531-47 PMID: 4353284
Lethality of the Escherichia coli K12 cell doubly deficient in DNA polymerase I and DNA strand-joining activity.
Mol Gen Genet. 1974;128(2):105-15 PMID: 4595549
Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase.
Nature. 1978 Aug 31;274(5674):891-3 PMID: 355897
Properties of a temperature-sensitive radiation-sensitive mutant of Escherichia coli.
Proc Natl Acad Sci U S A. 1968 Aug;60(4):1495-502 PMID: 4877274
Isolation and characterization of MMS-sensitive mutants of Saccharomyces cerevisiae.
Genetics. 1977 May;86(1):33-55 PMID: 195865

Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00268583

Published

1979-02-16

Pages

89-92

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00268583

Analysis Services

The DNA repair capability of cdc9, the Saccharomyces cerevisiae mutant defective in DNA ligase.

Contact

WeChat Official Account