Home LiteratureArticle Details
PMID: 2187593 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Vaccinia virus vectors: new strategies for producing recombinant vaccines.

Clinical microbiology reviews ·Vol. 3 ·No. 2 ·1990-04-00 ·Pages 153-70

Hruby DE

Abstract

The development and continued refinement of techniques for the efficient insertion and expression of heterologous DNA sequences from within the genomic context of infectious vaccinia virus recombinants are among the most promising current approaches towards effective immunoprophylaxis against a variety of protozoan, viral, and bacterial human pathogens. Because of its medical relevance, this area is the subject of intense research interest and has evolved rapidly during the past several years. This review (i) provides an updated overview of the technology that exists for assembling recombinant vaccinia virus strains, (ii) discusses the advantages and disadvantages of these approaches, (iii) outlines the areas of outgoing research directed towards overcoming the limitations of current techniques, and (iv) provides some insight (i.e., speculation) about probable future refinements in the use of vaccinia virus as a vector.

MeSH Terms
Animals Humans Vaccines Vaccines, Synthetic Vaccinia virus/immunology Viral Vaccines
Chemicals
Vaccines Vaccines, Synthetic Viral Vaccines
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hruby D E
Department of Microbiology, Oregon State University, Corvallis 97331-3804.
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.3.2.153
Published
1990-04-00
Pages
153-70
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC358149
Subset
IM
Grants
NIAID NIH HHS · AI00666 · United States
NIAID NIH HHS · AI26281 · United States
External Links
PubMed source DOI: 10.1128/CMR.3.2.153 PMC Full Text View journal details
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