Recombinant vaccinia virus: immunization against multiple pathogens.

Science (New York, N.Y.) ·Vol. 229 ·No. 4717 ·1985-09-06 ·Pages 981-4

Perkus ME, Piccini A, Lipinskas BR, Paoletti E

Abstract

The coding sequences for the hepatitis B virus surface antigen, the herpes simplex virus glycoprotein D, and the influenza virus hemagglutinin were inserted into a single vaccinia virus genome. Rabbits inoculated intravenously or intradermally with this polyvalent vaccinia virus recombinant produced antibodies reactive to all three authentic foreign antigens. In addition, the feasibility of multiple rounds of vaccination with recombinant vaccinia virus was demonstrated.

MeSH Terms

Animals Antigens, Viral/genetics DNA, Recombinant Glycoproteins/genetics,immunology Hemagglutinins, Viral/genetics,immunology Hepatitis B Surface Antigens/genetics,immunology Influenza A virus/genetics,immunology Rabbits Simplexvirus/genetics,immunology Vaccination Vaccinia virus/genetics,immunology Viral Proteins/genetics,immunology Viral Vaccines/genetics

Chemicals

Antigens, Viral DNA, Recombinant Glycoproteins Hemagglutinins, Viral Hepatitis B Surface Antigens Viral Proteins Viral Vaccines

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Perkus M E

Piccini A

Lipinskas B R

Paoletti E

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.2992092

Published

1985-09-06

Pages

981-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.2992092 View journal details

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