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PMID: 3472503 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Association of non-viral proteins with recombinant vaccinia virus virions.

Archives of virology ·Vol. 94 ·No. 3-4 ·1987-00-00 ·Pages 347-51

Franke CA, Hruby DE

Abstract

Evidence is presented which suggests that recombinant vaccinia virus particles (VV:CAT), containing the bacterial chloramphenicol acetyl transferase gene, are capable of encapsidating both the foreign protein which they encode (CAT) as well as cellular enzymes such as thymidine kinase. These results are discussed with respect to using VV to passively introduce biologically-active proteins into cells or organisms.

MeSH Terms
Acetyltransferases/genetics,metabolism Chloramphenicol O-Acetyltransferase DNA, Recombinant HeLa Cells Humans Thymidine Kinase/metabolism Vaccinia virus/enzymology,genetics,physiology Virion/enzymology
Chemicals
DNA, Recombinant Acetyltransferases Chloramphenicol O-Acetyltransferase Thymidine Kinase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Franke C A
Hruby D E
References (11)
11 references, click to expand
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01310729
Published
1987-00-00
Pages
347-51
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
Grants
NIAID NIH HHS · AI-00666 · United States
NIAID NIH HHS · AI-20563 · United States
External Links
PubMed source DOI: 10.1007/BF01310729 View journal details
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