Abstract
p97 is a cell surface glycoprotein expressed at high levels in most human melanomas but present only in trace amounts in normal adult tissues. We are interested in exploring the possibility of using recombinant vaccinia virus to express a specific tumor-associated antigen as a vaccine against human cancer. To this end, we constructed a recombinant virus, v-p97NY, which contains the entire coding sequence for p97 under the control of the vaccinia virus 7.5K promoter. Upon infection of tissue culture cells, v-p97NY expressed high levels of a membrane-bound glycoprotein immunoreactive with a p97-specific monoclonal antibody. Immunization of mice with this recombinant elicited high-titered antibodies against p97. Spleen cells isolated from these mice proliferated in vitro when stimulated either with purified p97 protein or with syngeneic cells expressing p97 antigen. Delayed-type hypersensitivity was also observed in immunized mice after challenge with p97-expressing cells. These findings indicate the potential usefulness of v-p97NY and similar recombinants in tumor immunotherapy.
MeSH Terms
Animals
Antigens, Neoplasm/genetics
Antigens, Surface/genetics,immunology
DNA, Recombinant
Genetic Vectors
Glycoproteins/genetics,immunology
Hypersensitivity, Delayed/immunology
Immunity, Cellular
Immunization
Melanoma/immunology
Melanoma-Specific Antigens
Mice
Neoplasm Proteins/genetics
Vaccinia virus/genetics
Chemicals
Antigens, Neoplasm
Antigens, Surface
DNA, Recombinant
Glycoproteins
Melanoma-Specific Antigens
Neoplasm Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hu S L
ONCOGEN, Seattle, Washington 98121.
Plowman G D
Sridhar P
Stevenson U S
Brown J P
Estin C D
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