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PMID: 17945508 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.

Seminars in cancer biology ·Vol. 18 ·No. 1 ·2008-02-00 ·Pages 53-64

Benjamin JM, Nelson WJ

Abstract

The cadherin/catenin complex, comprised of E-cadherin, beta-catenin and alpha-catenin, is essential for initiating cell-cell adhesion, establishing cellular polarity and maintaining tissue organization. Disruption or loss of the cadherin/catenin complex is common in cancer. As the primary cell-cell adhesion protein in epithelial cells, E-cadherin has long been studied in cancer progression. Similarly, additional roles for beta-catenin in the Wnt signaling pathway has led to many studies of the role of beta-catenin in cancer. Alpha-catenin, in contrast, has received less attention. However, recent data demonstrate novel functions for alpha-catenin in regulating the actin cytoskeleton and cell-cell adhesion, which when perturbed could contribute to cancer progression. In this review, we use cancer data to evaluate molecular models of alpha-catenin function, from the canonical role of alpha-catenin in cell-cell adhesion to non-canonical roles identified following conditional alpha-catenin deletion. This analysis identifies alpha-catenin as a prognostic factor in cancer progression.

MeSH Terms
Actin Cytoskeleton/physiology Actins/metabolism Animals Apoptosis Cadherins/metabolism Cell Adhesion Cell Polarity Cell Proliferation Humans Intercellular Signaling Peptides and Proteins/metabolism Neoplasm Metastasis Neoplasms/metabolism,pathology,physiopathology Signal Transduction alpha Catenin/metabolism beta Catenin/metabolism
Chemicals
Actins Cadherins Intercellular Signaling Peptides and Proteins alpha Catenin beta Catenin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Benjamin Jacqueline M
Department of Biological Sciences, Stanford University, 318 Campus Drive, Stanford, CA 94305-5430, USA.
Nelson W James
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Article Info
Journal
Seminars in cancer biology
Abbr.
Semin Cancer Biol
ISSN
1044-579X
DOI
10.1016/j.semcancer.2007.08.003
Published
2008-02-00
Epub
2007-00-04
Pages
53-64
Language
English
Region
England
NLM ID
9010218
PMCID
PMC2692220
Subset
IM
Grants
NINDS NIH HHS · R01 NS042735 · United States
NIGMS NIH HHS · R01 GM078270-03 · United States
NIGMS NIH HHS · GM 35527 · United States
NIGMS NIH HHS · R37 GM035527 · United States
NIGMS NIH HHS · R01 GM078270 · United States
NIGMS NIH HHS · R37 GM035527-25 · United States
NIGMS NIH HHS · R01 GM035527 · United States
NINDS NIH HHS · R01 NS042735-04 · United States
External Links
PubMed source DOI: 10.1016/j.semcancer.2007.08.003 PMC Full Text View journal details
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