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PMID: 12600316 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Sticky business: orchestrating cellular signals at adherens junctions.

Cell ·Vol. 112 ·No. 4 ·2003-02-21 ·Pages 535-48

Perez-Moreno M, Jamora C, Fuchs E

Abstract

Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions. These junctions and their cytoskeletal associations contribute heavily to the distinct shapes, polarity, spatially oriented mitotic spindle planes, and cellular movements of developing tissues. Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis.

MeSH Terms
Actins/metabolism Adherens Junctions Animals Cadherins/metabolism Cell Division Cytoskeleton/metabolism Down-Regulation Epithelial Cells Epithelium/physiology Fungal Proteins/metabolism GTP Phosphohydrolases/metabolism Humans Microscopy, Fluorescence Models, Biological Mutation Phosphorylation Signal Transduction rhoA GTP-Binding Protein/metabolism
Chemicals
Actins Cadherins Fungal Proteins GTP Phosphohydrolases rhoA GTP-Binding Protein
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Perez-Moreno Mirna
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.
Jamora Colin
Fuchs Elaine
Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
DOI
10.1016/s0092-8674(03)00108-9
Published
2003-02-21
Pages
535-48
Language
English
Region
United States
NLM ID
0413066
Subset
IM
Grants
NIAMS NIH HHS · R01 AR027883-28 · United States
External Links
PubMed source DOI: 10.1016/s0092-8674(03)00108-9 View journal details
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