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PMID: 10206308 Published · ppublish English Comparative Study Journal Article

E-cadherin and alpha-, beta- and gamma-catenin expression in prostate cancers: correlation with tumour invasion.

British journal of cancer ·Vol. 79 ·No. 11-12 ·1999-04-00 ·Pages 1879-83

Morita N, Uemura H, Tsumatani K, Cho M, Hirao Y, Okajima E, Konishi N, Hiasa Y

Abstract

The E-cadherin-catenin complex plays an important role in establishing and maintaining intercellular connections and morphogenesis and reduced expression of its constituent molecules is associated with invasion and metastasis. In the present study, we examined E-cadherin and alpha-, beta- and gamma-catenin levels in tumour tissues obtained by radical prostatectomy in order to investigate the relationship with histopathological tumour invasion. Immunohistochemical findings for 45 prostate cancer specimens demonstrated aberrant expression of each molecule to be associated with dedifferentiation and, in addition, alteration of staining patterns for the three types of catenin was significantly correlated with capsular but not lymphatic or vascular invasion. The data thus suggest that three types of catenin may be useful predictive markers for biological aggressiveness of prostate cancer.

MeSH Terms
Aged Cadherins/biosynthesis Cytoskeletal Proteins/biosynthesis Desmoplakins Humans Immunohistochemistry Male Middle Aged Neoplasm Invasiveness Prostatectomy Prostatic Neoplasms/metabolism,surgery Retrospective Studies Trans-Activators alpha Catenin beta Catenin gamma Catenin
Chemicals
CTNNA1 protein, human CTNNB1 protein, human Cadherins Cytoskeletal Proteins Desmoplakins JUP protein, human Trans-Activators alpha Catenin beta Catenin gamma Catenin
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Morita N
Department of Urology, Nara Medical University, Kashihara, Nara, Japan.
Uemura H
Tsumatani K
Cho M
Hirao Y
Okajima E
Konishi N
Hiasa Y
References (31)
31 references, click to expand
  1. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.
    J Cell Biol. 1994 Jun;125(6):1327-40 PMID: 8207061
  2. Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer.
    Virchows Arch. 1994;424(4):375-81 PMID: 8205352
  3. Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability.
    J Biol Chem. 1994 Dec 9;269(49):31214-23 PMID: 7983064
  4. Gene amplifications in advanced-stage human prostate cancer.
    Urol Res. 1995;22(6):343-7 PMID: 7740653
  5. Reduced alpha-catenin and E-cadherin expression in breast cancer.
    Lab Invest. 1995 May;72(5):506-12 PMID: 7745946
  6. c-met proto-oncogene expression in benign and malignant human prostate tissues.
    J Urol. 1995 Jul;154(1):293-8 PMID: 7539865
  7. Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines.
    Oncogene. 1995 Oct 5;11(7):1319-26 PMID: 7478552
  8. E-cadherin expression in bladder cancer using formalin-fixed, paraffin-embedded tissues: correlation with histopathological grade, tumour stage and survival.
    Int J Cancer. 1995 Dec 20;64(6):367-70 PMID: 8550236
  9. Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer.
    Am J Clin Pathol. 1996 Apr;105(4):394-402 PMID: 8604681
  10. Screening and early detection of prostate cancer will decrease morbidity and mortality from prostate cancer: the argument against.
    Eur Urol. 1996;29 Suppl 2:24-6 PMID: 8717457
  11. Prognostic value of cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120cas) in bladder tumors.
    Cancer Res. 1996 Sep 15;56(18):4154-8 PMID: 8797585
  12. Dominant negative inhibition of the association between beta-catenin and c-erbB-2 by N-terminally deleted beta-catenin suppresses the invasion and metastasis of cancer cells.
    Oncogene. 1996 Sep 5;13(5):883-9 PMID: 8806677
  13. Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: relationship with patient survival.
    Gastroenterology. 1997 Jan;112(1):46-54 PMID: 8978342
  14. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
    Science. 1997 Mar 21;275(5307):1784-7 PMID: 9065401
  15. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
    Science. 1997 Mar 21;275(5307):1787-90 PMID: 9065402
  16. Cleaning up on beta-catenin.
    Nat Med. 1997 May;3(5):499-500 PMID: 9142114
  17. Immunohistochemical detection of E-cadherin in differentiated thyroid carcinomas correlates with clinical outcome.
    Cancer Res. 1997 Jun 15;57(12):2501-7 PMID: 9192832
  18. Aberrant E-cadherin and alpha-catenin expression in prostate cancer: correlation with patient survival.
    Cancer Res. 1997 Aug 1;57(15):3189-93 PMID: 9242448
  19. Relation between aberrant alpha-catenin expression and loss of E-cadherin function in prostate cancer.
    Int J Cancer. 1997 Aug 22;74(4):374-7 PMID: 9291424
  20. The results of prostate carcinoma screening in the U.S. as reflected in the surveillance, epidemiology, and end results program.
    Cancer. 1997 Nov 1;80(9):1835-44 PMID: 9351557
  21. Cancer incidence and mortality in the European Union: cancer registry data and estimates of national incidence for 1990.
    Eur J Cancer. 1997 Jun;33(7):1075-107 PMID: 9376190
  22. Prognostic significance of tumor grade and stage in the patient with carcinoma of the prostate.
    Prostate. 1983;4(1):13-31 PMID: 6340082
  23. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.
    J Cell Biol. 1989 Jun;108(6):2435-47 PMID: 2661563
  24. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.
    EMBO J. 1989 Jun;8(6):1711-7 PMID: 2788574
  25. The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression.
    Cell. 1991 May 31;65(5):849-57 PMID: 1904011
  26. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.
    Cell. 1991 Jul 12;66(1):107-19 PMID: 2070412
  27. Decreased expression of E-cadherin in the progression of rat prostatic cancer.
    Cancer Res. 1992 May 15;52(10):2916-22 PMID: 1581909
  28. Cancer statistics, 1993.
    CA Cancer J Clin. 1993 Jan-Feb;43(1):7-26 PMID: 8422609
  29. E-cadherin and alpha-catenin expression in human esophageal cancer.
    Cancer Res. 1994 Jan 1;54(1):291-6 PMID: 8261454
  30. Frequent loss of alpha catenin expression in scirrhous carcinomas with scattered cell growth.
    Jpn J Cancer Res. 1994 Mar;85(3):266-73 PMID: 8188525
  31. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer.
    Cancer Res. 1994 Jul 15;54(14):3929-33 PMID: 7518346
Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/sj.bjc.6690299
Published
1999-04-00
Pages
1879-83
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2362820
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.bjc.6690299 PMC Full Text View journal details
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