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PMID: 12888830 Published · ppublish English Journal Article

Expression of E-cadherin, alpha-catenin, and beta-catenin in the process of lymph node metastasis in oral squamous cell carcinoma.

British journal of cancer ·Vol. 89 ·No. 3 ·2003-08-04 ·Pages 557-63

Tanaka N, Odajima T, Ogi K, Ikeda T, Satoh M

Abstract

Regional lymph node metastasis is a very important prognostic indicator. In the metastatic process, reduction in cell to cell adhesion including E-cadherin-catenin cell adhesion complex is an essential step. We investigated immunohistochemical expression of E-cadherin, alpha-catenin and beta-catenin in 159 tissue samples from patients with oral squamous cell carcinoma and examined the correlation between their expressions and the presence of regional lymph node metastasis. Significantly greater reduction in expression levels of E-cadherin, alpha-catenin and beta-catenin was found in the metastatic group (n=64) compared to the nonmetastatic group (n=95) (P=0.007, 0.001, 0.001, respectively). However, there was no significant correlation between their expressions and the features of the regional metastasis, the number of metastatic lymph nodes or the presence of extracapsular metastasis. These data suggest that evaluation of the immunohistochemical expression of E-cadherin, alpha-catenin and beta-catenin is extremely valuable for the diagnosis of metastatic occurrence.

MeSH Terms
Adult Aged Aged, 80 and over Cadherins/biosynthesis Carcinoma, Squamous Cell/genetics,physiopathology Cytoskeletal Proteins/biosynthesis Female Gene Expression Regulation Gingival Neoplasms/genetics,physiopathology Humans Immunohistochemistry Male Middle Aged Neoplasm Metastasis/physiopathology Tongue Neoplasms/genetics,physiopathology Trans-Activators/biosynthesis alpha Catenin beta Catenin
Chemicals
CTNNA1 protein, human CTNNB1 protein, human Cadherins Cytoskeletal Proteins Trans-Activators alpha Catenin beta Catenin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Tanaka N
Department of Oral Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuou-ku Sapporo 060-0061 Japan.
Odajima T
Ogi K
Ikeda T
Satoh M
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/sj.bjc.6601124
Published
2003-08-04
Pages
557-63
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2394393
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.bjc.6601124 PMC Full Text View journal details
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