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PMID: 12776176 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

IQGAP proteins are integral components of cytoskeletal regulation.

EMBO reports ·Vol. 4 ·No. 6 ·2003-06-00 ·Pages 571-4

Briggs MW, Sacks DB

Abstract

IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural molecules. By interacting with its target proteins, human IQGAP1 participates in multiple cellular functions, including Ca(2+)/calmodulin signalling, cytoskeletal architecture, CDC42 and Rac signalling, E-cadherin-mediated cell-cell adhesion and beta-catenin-mediated transcription. Yeast IQGAP homologues are important regulators of cellular morphogenesis because they are required for budding and cytokinesis. Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.

MeSH Terms
Animals Cell Division Cytoskeletal Proteins/metabolism Cytoskeleton/metabolism Humans Microfilament Proteins/chemistry,physiology Models, Biological Neoplasms/metabolism Protein Binding Protein Structure, Tertiary Signal Transduction Trans-Activators/metabolism Transcription, Genetic beta Catenin ras GTPase-Activating Proteins
Chemicals
CTNNB1 protein, human Cytoskeletal Proteins IQ motif containing GTPase activating protein 1 Microfilament Proteins Trans-Activators beta Catenin ras GTPase-Activating Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Briggs Michael W
Brigham and Women's Hospital, Thorn 530, 75 Francis Street, Boston, MA 02115, USA.
Sacks David B
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41 references, click to expand
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.embor867
Published
2003-06-00
Pages
571-4
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1319206
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.embor.embor867 PMC Full Text View journal details
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