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PMID: 17084354 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Catenins: keeping cells from getting their signals crossed.

Developmental cell ·Vol. 11 ·No. 5 ·2006-11-00 ·Pages 601-12

Perez-Moreno M, Fuchs E

Abstract

Adherens junctions have been traditionally viewed as building blocks of tissue architecture. The foundations for this view began to change with the discovery that a central component of AJs, beta-catenin, can also function as a transcriptional cofactor in Wnt signaling. In recent years, conventional views have similarly been shaken about the other two major AJ catenins, alpha-catenin and p120-catenin. Catenins have emerged as molecular sensors that integrate cell-cell junctions and cytoskeletal dynamics with signaling pathways that govern morphogenesis, tissue homeostasis, and even intercellular communication between different cell types within a tissue. These findings reveal novel aspects of AJ function in normal tissues and offer insights into how changes in AJs and their associated proteins and cytoskeletal dynamics impact wound-repair and cancer.

MeSH Terms
Actins/metabolism Adherens Junctions/physiology Animals Catenins Cell Adhesion Molecules/physiology Cell Communication/physiology Cell Cycle/physiology Cytoskeleton/physiology Inflammation/pathology Neoplasms/pathology Phosphoproteins/physiology Signal Transduction/physiology Wound Healing/physiology alpha Catenin/physiology beta Catenin/physiology
Chemicals
Actins Catenins Cell Adhesion Molecules Phosphoproteins alpha Catenin beta Catenin delta catenin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Perez-Moreno Mirna
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA.
Fuchs Elaine
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Article Info
Journal
Developmental cell
Abbr.
Dev Cell
ISSN
1534-5807
DOI
10.1016/j.devcel.2006.10.010
Published
2006-11-00
Pages
601-12
Language
English
Region
United States
NLM ID
101120028
PMCID
PMC2405914
Subset
IM
Grants
NIAMS NIH HHS · R01 AR027883 · United States
NIAMS NIH HHS · R01 AR027883-28 · United States
NIAMS NIH HHS · R37 AR027883 · United States
NIAMS NIH HHS · AR27883 · United States
External Links
PubMed source DOI: 10.1016/j.devcel.2006.10.010 PMC Full Text View journal details
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