Home LiteratureArticle Details
PMID: 12507993 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Direct cadherin-activated cell signaling: a view from the plasma membrane.

The Journal of cell biology ·Vol. 160 ·No. 1 ·2003-01-06 ·Pages 11-6

Yap AS, Kovacs EM

Abstract

Classical cadherin adhesion molecules are key determinants of cell recognition and tissue morphogenesis, with diverse effects on cell behavior. Recent developments indicate that classical cadherins are adhesion-activated signaling receptors. In particular, early-immediate Rac signaling is emerging as a mechanism to coordinate cadherin-actin integration at the plasma membrane.

MeSH Terms
Animals Cadherins/metabolism Cell Adhesion Cell Membrane/metabolism Enzyme Activation Humans Models, Biological Protein Binding Signal Transduction rho GTP-Binding Proteins/metabolism
Chemicals
Cadherins rho GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Yap Alpha S
School for Biomedical Science and Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072. a.yap@mailbox.uq.edu.au
Kovacs Eva M
References (48)
48 references, click to expand
  1. Directed actin polymerization is the driving force for epithelial cell-cell adhesion.
    Cell. 2000 Jan 21;100(2):209-19 PMID: 10660044
  2. Interplay between Rac and Rho in the control of substrate contact dynamics.
    Curr Biol. 1999 Jun 17;9(12):640-8 PMID: 10375527
  3. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells.
    Annu Rev Biophys Biomol Struct. 2000;29:545-76 PMID: 10940259
  4. Inhibition of RhoA by p120 catenin.
    Nat Cell Biol. 2000 Sep;2(9):637-44 PMID: 10980705
  5. Rho family GTPases: more than simple switches.
    Trends Cell Biol. 2000 Oct;10(10):415-9 PMID: 10998597
  6. Epithelial cell shape: cadherins and small GTPases.
    Exp Cell Res. 2000 Nov 25;261(1):83-90 PMID: 11082278
  7. E-cadherin-mediated cell-cell attachment activates Cdc42.
    J Biol Chem. 2000 Nov 24;275(47):36999-7005 PMID: 10950951
  8. Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation.
    J Biol Chem. 2000 Dec 29;275(52):41227-33 PMID: 10969083
  9. Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.
    Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):519-24 PMID: 11136230
  10. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites.
    J Cell Sci. 2001 May;114(Pt 10):1829-38 PMID: 11329369
  11. Rac1 protects epithelial cells against anoikis.
    J Biol Chem. 2001 Jul 27;276(30):28113-20 PMID: 11369774
  12. Cadherin engagement regulates Rho family GTPases.
    J Biol Chem. 2001 Sep 7;276(36):33305-8 PMID: 11457821
  13. Abelson kinase regulates epithelial morphogenesis in Drosophila.
    J Cell Biol. 2001 Dec 24;155(7):1185-98 PMID: 11756472
  14. Cadherin-mediated cell sorting not determined by binding or adhesion specificity.
    J Cell Biol. 2002 Jan 21;156(2):389-399 PMID: 11790800
  15. E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts.
    J Biol Chem. 2002 Feb 22;277(8):6708-18 PMID: 11744701
  16. Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts.
    Curr Biol. 2002 Mar 5;12(5):379-82 PMID: 11882288
  17. VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam.
    Mol Biol Cell. 2002 Apr;13(4):1175-89 PMID: 11950930
  18. Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton.
    J Cell Biol. 2002 Apr 29;157(3):469-79 PMID: 11970959
  19. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch.
    Genes Dev. 2002 Jul 1;16(13):1587-609 PMID: 12101119
  20. Cadherin regulates dendritic spine morphogenesis.
    Neuron. 2002 Jul 3;35(1):77-89 PMID: 12123610
  21. Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila.
    Development. 2002 Aug;129(16):3771-82 PMID: 12135916
  22. Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion.
    Dev Cell. 2002 Aug;3(2):259-70 PMID: 12194856
  23. N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts.
    J Cell Biol. 2002 Sep 2;158(5):953-65 PMID: 12213839
  24. Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium.
    Dev Cell. 2002 Sep;3(3):367-81 PMID: 12361600
  25. Molecular mechanism for orienting membrane and actin dynamics to nascent cell-cell contacts in epithelial cells.
    J Biol Chem. 2002 Nov 22;277(47):45371-6 PMID: 12244058
  26. Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps.
    J Cell Biol. 1994 Jul;126(2):519-27 PMID: 8034750
  27. Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.
    Cell. 1994 Dec 2;79(5):791-803 PMID: 7528101
  28. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase.
    Curr Biol. 1995 Apr 1;5(4):393-403 PMID: 7627555
  29. Lateral dimerization is required for the homophilic binding activity of C-cadherin.
    J Cell Biol. 1996 Oct;135(2):487-96 PMID: 8896604
  30. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex.
    J Biol Chem. 1999 Jul 2;274(27):19347-51 PMID: 10383446
  31. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
    Cell. 1999 Jul 23;98(2):147-57 PMID: 10428027
  32. Cadherins and their connections: adhesion junctions have broader functions.
    Curr Opin Cell Biol. 1999 Oct;11(5):554-60 PMID: 10508659
  33. Interaction of the adaptor protein Shc and the adhesion molecule cadherin.
    J Biol Chem. 1997 May 23;272(21):13463-6 PMID: 9153187
  34. Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function.
    Curr Biol. 1997 May 1;7(5):308-15 PMID: 9133345
  35. Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells.
    J Cell Biol. 1997 Nov 17;139(4):1047-59 PMID: 9362522
  36. Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.
    Science. 1997 Nov 21;278(5342):1464-6 PMID: 9367959
  37. Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases.
    Biochem Biophys Res Commun. 1997 Nov 17;240(2):430-5 PMID: 9388496
  38. Rho GTPases and the actin cytoskeleton.
    Science. 1998 Jan 23;279(5350):509-14 PMID: 9438836
  39. Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity.
    J Cell Biol. 1998 Jul 13;142(1):85-100 PMID: 9660865
  40. Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein.
    J Cell Biol. 1998 Aug 24;142(4):1105-19 PMID: 9722621
  41. Rapid epithelial-sheet sealing in the Caenorhabditis elegans embryo requires cadherin-dependent filopodial priming.
    Curr Biol. 1999 Oct 21;9(20):1139-46 PMID: 10531027
  42. Drosophila oocyte localization is mediated by differential cadherin-based adhesion.
    Nature. 1998 Sep 24;395(6700):387-91 PMID: 9759729
  43. Cytomechanics of cadherin-mediated cell-cell adhesion.
    Curr Opin Cell Biol. 1998 Oct;10(5):572-7 PMID: 9818166
  44. The tumor-suppressor function of E-cadherin.
    Am J Hum Genet. 1998 Dec;63(6):1588-93 PMID: 9837810
  45. Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context.
    Mol Biol Cell. 1999 Jan;10(1):9-22 PMID: 9880323
  46. Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction.
    Curr Biol. 1999 Apr 22;9(8):433-6 PMID: 10226029
  47. Cadherins and tissue formation: integrating adhesion and signaling.
    Bioessays. 1999 Mar;21(3):211-20 PMID: 10333730
  48. p120 catenin regulates the actin cytoskeleton via Rho family GTPases.
    J Cell Biol. 2000 Aug 7;150(3):567-80 PMID: 10931868
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200208156
Email
a.yap@mailbox.uq.edu.au
Published
2003-01-06
Epub
2002-00-30
Pages
11-6
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2172751
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1083/jcb.200208156 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2