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PMID: 15484291 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Prognostic and clinicopathological features of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma.

World journal of gastroenterology ·Vol. 10 ·No. 22 ·2004-11-15 ·Pages 3235-9

Lin YC, Wu MY, Li DR, Wu XY, Zheng RM

Abstract

To investigate the expression of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D(1) in patients with esophageal squamous cell carcinoma (ESCC), and analyze their interrelationship with clinicopathological variables and their effects on prognosis. Expression of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D(1) was determined by EnVision or SABC immunohistochemical technique in patients with ESCC consecutively, their correlation with clinical characteristics was evaluated and analyzed by univariate analysis. The reduced expression rate of E-cadherin, alpha-catenin, beta-catenin and gamma-catenin was 88.7%, 69.4%, 35.5% and 53.2%, respectively. Cyclin D1 positive expression rate was 56.5%. Expression of gamma-catenin was inversely correlated with the degree of tumor differentiation and lymph node metastasis (chi(2) = 4.183 and chi(2) = 5.035, respectively, P<0.05), whereas the expression of E-cadherin was correlated only with the degree of differentiation (chi(2) = 5.769, P<0.05). Reduced expression of E-cadherin and gamma-catenin was associated with poor differentiation of tumor, reduced expression of gamma-catenin was also associated with lymph node metastasis. There obviously existed an inverse correlation between level of E-cadherin and gamma-catenin protein and survival. The 3-year survival rates were 100% and 56% in E-cadherin preserved expression group and in reduced expression one and were 78% and 48% in gamma-catenin preserved expression group and in reduced expression one, respectively. The differences were both statistically significant. Correlation analysis showed the expression level of alpha-catenin correlated with that of E-cadherin and beta-catenin (P<0.05). The reduced expression of E-cadherin and gamma-catenin, but not alpha-catenin, beta-catenin and cyclin D1, implies more aggressive malignant behaviors of esophageal carcinoma cells and predicts the poor prognosis of patients.

MeSH Terms
Biomarkers, Tumor/metabolism Cadherins/metabolism Carcinoma, Squamous Cell/metabolism,mortality,pathology Cyclin D1/metabolism Cytoskeletal Proteins/metabolism Desmoplakins Esophageal Neoplasms/metabolism,mortality,pathology Humans Immunohistochemistry Prognosis Survival Rate Trans-Activators/metabolism alpha Catenin beta Catenin gamma Catenin
Chemicals
Biomarkers, Tumor CTNNA1 protein, human CTNNB1 protein, human Cadherins Cytoskeletal Proteins Desmoplakins JUP protein, human Trans-Activators alpha Catenin beta Catenin gamma Catenin Cyclin D1
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lin Ying-Cheng
Department of Medical Oncology, Tumor Hospital, Shantou University Medical College, Shantou 515031, Guangdong Province, China. linyingcheng@medmail.com.cn
Wu Ming-Yao
Li De-Rui
Wu Xian-Ying
Zheng Rui-Ming
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Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
1007-9327
DOI
10.3748/wjg.v10.i22.3235
Email
linyingcheng@medmail.com.cn
Published
2004-11-15
Pages
3235-9
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC4572286
Subset
IM
External Links
PubMed source DOI: 10.3748/wjg.v10.i22.3235 PMC Full Text View journal details
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