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PMID: 11819849 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China.

World journal of gastroenterology ·Vol. 7 ·No. 5 ·2001-10-00 ·Pages 657-61

Su M, Lu SM, Tian DP, Zhao H, Li XY, Li DR, Zheng ZC

Abstract

To study the relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China, which is a unique Littoral high-risk area of esophageal carcinoma in China. The poor communication and transportation in the past has made Chaoshan a relatively closed area and kept its culture and custure of old China thousand years ago. Data on age, sex, ABO blood type and X-ray or pathological diagnose of the patients with carcinoma of esophagus or cardia were collected from the Tumor Hospital. First Affiliated Hospital, Second Affiliated Hospital of Shantou University Medical College; and the Central Hospital of Shantou and the Central Hospital of Jieyang. A total of 6685 patients with esophageal carcinoma (EC) and 2955 patients with cardiac cancer (CC) in Chaoshan district were retrospectively assessed for their association with ABO blood groups. The distribution of ABO blood groups in patients with EC or CC was similar to the normal local population in Chaoshan. However, blood group B in male patients with CC and in the patients with carcinoma in the upper third esophagus was 2.3% and 4.7% higher than the corresponding controls. The relative risk B O was 1.1415 (P<0.05) and 1.2696 (P<0.05), respectively. No relationship was found between ABO blood groups and tumor differentiation. ABO blood group B is associated with the incidence of CC in male individuals and carcinoma in the upper third esophagus. The distribution of ABO blood groups varies in the different geographical and ethnic groups. As a result, proper controls are very important for such studies.

MeSH Terms
ABO Blood-Group System/genetics Cardia China/epidemiology Esophageal Neoplasms/epidemiology,genetics Female Gene Frequency Genetic Predisposition to Disease Humans Male Retrospective Studies Risk Factors Sex Distribution Stomach Neoplasms/epidemiology,genetics
Chemicals
ABO Blood-Group System
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Su M
Department of Pathology, Shantou University Medical College, Shantou 515031,China. minsu@ncrc.stu.edu.cn
Lu S M
Tian D P
Zhao H
Li X Y
Li D R
Zheng Z C
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Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
1007-9327
DOI
10.3748/wjg.v7.i5.657
Email
minsu@ncrc.stu.edu.cn
Published
2001-10-00
Pages
657-61
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC4695569
Subset
IM
External Links
PubMed source DOI: 10.3748/wjg.v7.i5.657 PMC Full Text View journal details
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