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PMID: 2181258 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Nucleotide excision repair in Escherichia coli.

Microbiological reviews ·Vol. 54 ·No. 1 ·1990-03-00 ·Pages 18-51

Van Houten B

Abstract

One of the best-studied DNA repair pathways is nucleotide excision repair, a process consisting of DNA damage recognition, incision, excision, repair resynthesis, and DNA ligation. Escherichia coli has served as a model organism for the study of this process. Recently, many of the proteins that mediate E. coli nucleotide excision have been purified to homogeneity; this had led to a molecular description of this repair pathway. One of the key repair enzymes of this pathway is the UvrABC nuclease complex. The individual subunits of this enzyme cooperate in a complex series of partial reactions to bind to and incise the DNA near a damaged nucleotide. The UvrABC complex displays a remarkable substrate diversity. Defining the structural features of DNA lesions that provide the specificity for damage recognition by the UvrABC complex is of great importance, since it represents a unique form of protein-DNA interaction. Using a number of in vitro assays, researchers have been able to elucidate the action mechanism of the UvrABC nuclease complex. Current research is devoted to understanding how these complex events are mediated within the living cell.

MeSH Terms
Amino Acid Sequence Base Sequence DNA Repair/physiology DNA, Bacterial/genetics Endodeoxyribonucleases/genetics Escherichia coli/genetics Escherichia coli Proteins Molecular Sequence Data
Chemicals
DNA, Bacterial Escherichia coli Proteins Endodeoxyribonucleases endodeoxyribonuclease uvrABC
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Van Houten B
Department of Pathology, University of Vermont, Burlington 05405.
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Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.54.1.18-51.1990
Published
1990-03-00
Pages
18-51
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC372757
Subset
IM
External Links
PubMed source DOI: 10.1128/mr.54.1.18-51.1990 PMC Full Text
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