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PMID: 9880473 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Role of heat shock proteins in protection from and pathogenesis of infectious diseases.

Clinical microbiology reviews ·Vol. 12 ·No. 1 ·1999-01-00 ·Pages 19-39

Zügel U, Kaufmann SH

Abstract

Increased synthesis of heat shock proteins (hsp) occurs in prokaryotic and eukaryotic cells when they are exposed to stress. By increasing their hsp content, cells protect themselves from lethal assaults, primarily because hsp interfere with the uncontrolled protein unfolding that occurs under stress. However, hsp are not produced only by stressed cells; some hsp are synthesized constitutively and perform important housekeeping functions. Accordingly, hsp are involved in the assembly of molecules which play important roles in the immune system. It is not surprising that due to their wide distribution and their homology among different species, hsp represent target antigens of the immune response. Frequent confrontation of the immune system with conserved regions of hsp which are shared by various microbial pathogens can potentiate antimicrobial immunity. However, long-term confrontation of the immune system with hsp antigens which are similar in the host and invaders may convert the immune response against these host antigens and promote autoimmune disease. This review provides an overview of the role of hsp in immunity with a focus on infectious and autoimmune diseases.

MeSH Terms
Animals Heat-Shock Proteins/immunology,physiology Humans Infections/etiology,immunology
Chemicals
Heat-Shock Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zügel U
Department of Immunology, University Clinics Ulm, 89070 Ulm, Germany. ulrich.zuegel@medizin.uni-ulm.de
Kaufmann S H
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.12.1.19
Email
ulrich.zuegel@medizin.uni-ulm.de
Published
1999-01-00
Pages
19-39
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC88905
Subset
IM
External Links
PubMed source DOI: 10.1128/CMR.12.1.19 PMC Full Text View journal details
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