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PMID: 9284177 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Activation of CD8 T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guérin-vaccinated mice.

Infection and immunity ·Vol. 65 ·No. 9 ·1997-09-00 ·Pages 3947-50

Zügel U, Kaufmann SH

Abstract

Heat shock protein 60 (hsp60)-specific CD8 T cells lysed Mycobacterium bovis BCG-infected macrophages in vitro and adoptively transferred protection against mycobacterial infection. Moreover, CD8 T cells with this hsp60 specificity were activated in vivo by BCG vaccination. Our studies suggest there is participation of hsp60-specific CD8 T cells in BCG-induced immunity.

MeSH Terms
Adoptive Transfer Animals BCG Vaccine/immunology CD8-Positive T-Lymphocytes/immunology Chaperonin 60/immunology Cytotoxicity, Immunologic Lymphocyte Activation Macrophages/immunology,microbiology Mice Mycobacterium bovis/immunology Spleen/immunology T-Lymphocytes, Cytotoxic/immunology
Chemicals
BCG Vaccine Chaperonin 60
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zügel U
Department of Immunology, University of Ulm, Germany.
Kaufmann S H
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21 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.65.9.3947-3950.1997
Published
1997-09-00
Pages
3947-50
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC175564
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.65.9.3947-3950.1997 PMC Full Text View journal details
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