The role of hsp90 in SLE.

Autoimmunity ·Vol. 19 ·No. 3 ·1994-00-00 ·Pages 211-8

Latchman DS, Isenberg DA

Abstract

The heat shock proteins are a group of evolutionarily conserved proteins with important physiological functions, whose synthesis is enhanced by elevated temperature or other stresses. A role for one or more of these proteins in human autoimmune disease has been extensively discussed. This review considers the evidence of a role for hsp90 in systemic lupus erythematosus (SLE) where overexpression of this protein, its surface localization and auto-antibodies to it have been observed in both human patients and in the MRL/lpr mouse model of SLE.

MeSH Terms

Animals Autoantibodies/immunology Autoantigens/biosynthesis,genetics,immunology Autoimmune Diseases/genetics,immunology Disease Models, Animal Disease Susceptibility/immunology Gene Expression Regulation Genetic Predisposition to Disease HLA-A1 Antigen/genetics HLA-B8 Antigen/genetics HLA-DR3 Antigen/genetics HSP90 Heat-Shock Proteins/biosynthesis,genetics,immunology Haplotypes/immunology Humans Lupus Erythematosus, Systemic/genetics,immunology Lymphoproliferative Disorders/genetics,immunology Mice Mice, Mutant Strains Models, Immunological

Chemicals

Autoantibodies Autoantigens HLA-A1 Antigen HLA-B8 Antigen HLA-DR3 Antigen HSP90 Heat-Shock Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Latchman D S

Department of Molecular Pathology, University College London Medical School.

Isenberg D A

Article Info

Journal

Autoimmunity

Abbr.

Autoimmunity

ISSN

0891-6934

DOI

10.3109/08916939408995696

Published

1994-00-00

Pages

211-8

Language

English

Region

England

NLM ID

8900070

Subset

External Links

PubMed source DOI: 10.3109/08916939408995696 View journal details

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The role of hsp90 in SLE.

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