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PMID: 7680870 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Cell biology of antigen presentation.

Current opinion in immunology ·Vol. 5 ·No. 1 ·1993-02-00 ·Pages 27-34

Neefjes JJ, Momburg F

Abstract

MHC class I molecules present degradation products derived from intracellular proteins, whereas MHC class II molecules generally present peptides derived from extracellular or surface proteins. Recent insights into the cell biology of MHC class I and II molecules explain this difference.

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MeSH Terms

Animals Antigen-Presenting Cells/immunology,metabolism Antigens/immunology,metabolism Biological Transport Endocytosis Endopeptidases/metabolism Epitopes/immunology,metabolism Histocompatibility Antigens Class I/immunology,metabolism Histocompatibility Antigens Class II/immunology,metabolism Humans Mice Models, Biological Peptide Fragments/immunology,metabolism Protein Binding beta 2-Microglobulin/metabolism

Chemicals

Antigens Epitopes Histocompatibility Antigens Class I Histocompatibility Antigens Class II Peptide Fragments beta 2-Microglobulin Endopeptidases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Neefjes J J

The Netherlands Cancer Institute, Amsterdam.

Momburg F

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/0952-7915(93)90077-6

Published

1993-02-00

Pages

27-34

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/0952-7915(93)90077-6 View journal details

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