Abstract
We have examined the immunogenicity of complexes formed by non-covalent association of a synthetic peptide corresponding to influenza A virus nucleoprotein, residues 206-229 (pNP) and Mycobacterium tuberculosis heat-shock protein 70 (hsp 70). One or two injections of these complexes given to BALB/c mice without any additional adjuvant, were capable of eliciting very strong peptide-specific proliferative T-cell responses in the spleen. These responses were dependent on the stability of the complex since immunogenicity was lost when dissociated with ATP prior to immunization. T-cell responses to hsp 70 were easily generated by immunization with the purified chaperone alone, either after primary or secondary immunization. Injection of pNP-hsp 70 complexes, however, although generating good primary responses, resulted in very much decreased proliferative responses to the hsp 70.
MeSH Terms
Adenosine Triphosphate/pharmacology
Amino Acid Sequence
Animals
Antigens, Bacterial/immunology
Cell Division/drug effects,immunology
Electrophoresis, Polyacrylamide Gel
HSP70 Heat-Shock Proteins/immunology
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mycobacterium tuberculosis/immunology
Nucleocapsid Proteins
Nucleoproteins/immunology
RNA-Binding Proteins
Spleen/immunology
T-Lymphocytes/immunology
Vaccines, Synthetic/immunology
Viral Core Proteins/immunology
Chemicals
Antigens, Bacterial
HSP70 Heat-Shock Proteins
NP protein, Influenza A virus
Nucleocapsid Proteins
Nucleoproteins
RNA-Binding Proteins
Vaccines, Synthetic
Viral Core Proteins
Adenosine Triphosphate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Román E
MRC Tuberculosis and Related Infections Unit, Royal Postgraduate Medical School, London, UK.
Moreno C
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