Home LiteratureArticle Details

PMID: 2234077 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.

Nature ·Vol. 348 ·No. 6297 ·1990-11-08 ·Pages 137-43

Kang PJ, Ostermann J, Shilling J, Neupert W, Craig EA, Pfanner N

Abstract

By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.

Related Genes

Ssc1p

MeSH Terms

Biological Transport Cell Compartmentation Cloning, Molecular DNA Mutational Analysis Fungal Proteins HSP70 Heat-Shock Proteins Heat-Shock Proteins/physiology Mitochondria/physiology Mutation Protein Conformation Protein Precursors/metabolism Protein Processing, Post-Translational Protozoan Proteins

Chemicals

Fungal Proteins HSP70 Heat-Shock Proteins Heat-Shock Proteins Protein Precursors Protozoan Proteins mtp70 protein, Trypanosoma cruzi

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kang P J

Department of Physiological Chemistry, University of Wisconsin, Madison 53706.

Ostermann J

Shilling J

Neupert W

Craig E A

Pfanner N

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/348137a0

Published

1990-11-08

Pages

137-43

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/348137a0 View journal details

Analysis Services

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.

Contact

WeChat Official Account