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PMID: 1634255 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Surface expressed heat-shock proteins by stressed or human immunodeficiency virus (HIV)-infected lymphoid cells represent the target for antibody-dependent cellular cytotoxicity.

Immunology ·Vol. 76 ·No. 2 ·1992-06-00 ·Pages 341-3

Di Cesare S, Poccia F, Mastino A, Colizzi V

Abstract

The expression of heat-shock proteins (HSP) of the 72,000 MW family by Daudi and H9 lymphoma cells has been investigated by flow cytometry. It has been found that both heat-stressed and chronically human immunodeficiency virus (HIV)-infected lymphomas show an increased expression of heat-shock proteins (HSP). Moreover, murine monoclonal antibody (mAb) against 72,000 MW HSP was able to mediate antibody-dependent cellular cytotoxicity (ADCC) using peripheral blood lymphocytes (PBL) as effector cells. All target cells used in these experiments were efficiently lysed in the presence of anti-HSP antibody suggesting a role of membrane HSP in the elimination of stressed or infected cells.

MeSH Terms

Antibody-Dependent Cell Cytotoxicity/immunology HIV Infections/immunology Heat-Shock Proteins/analysis,immunology Humans Killer Cells, Natural/immunology Neoplasm Proteins/analysis Tumor Cells, Cultured/chemistry

Chemicals

Heat-Shock Proteins Neoplasm Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Di Cesare S

Department of Biology, University of Rome Tor Vergata, Italy.

Poccia F

Mastino A

Colizzi V

References (12)

12 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1992-06-00

Pages

341-3

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1421542

Subset

External Links

PubMed source PMC Full Text View journal details

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Surface expressed heat-shock proteins by stressed or human immunodeficiency virus (HIV)-infected lymphoid cells represent the target for antibody-dependent cellular cytotoxicity.

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