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PMID: 8902580 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Contribution of 65-kDa heat shock protein induced by gamma and delta T cells to protection against Toxoplasma gondii infection.

Immunologic research ·Vol. 15 ·No. 3 ·1996-00-00 ·Pages 258-64

Himeno K, Hisaeda H

Abstract

Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, Toxoplasma gondii, in mice. Experiments using low and highly virulent strains of Tox. gondii revealed that induction of murine HSP65 on macrophages closely correlates with protection against infection with this protozoan. Furthermore, we clarified that T cells, especially gamma delta T cells, are indispensable for HSP65 expression. A similar relationship between the expression of HSP65 on host macrophages and protective immunity was observed in mice infected with Leishmania major and Trypanosoma cruzi, both of which are obligate intracellular protozoa as is Tox. gondii.

MeSH Terms

Animals Antigens, Bacterial/immunology Bacterial Proteins Chaperonin 60 Chaperonins/biosynthesis,physiology Receptors, Antigen, T-Cell, gamma-delta/immunology T-Lymphocyte Subsets/physiology Toxoplasma/immunology Toxoplasmosis, Animal/immunology,prevention & control

Chemicals

Antigens, Bacterial Bacterial Proteins Chaperonin 60 Receptors, Antigen, T-Cell, gamma-delta heat-shock protein 65, Mycobacterium Chaperonins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Himeno K

Department of Parasitology and Immunology, School of Medicine, University of Tokushima, Japan.

Hisaeda H

References (22)

22 references, click to expand

T cells against a bacterial heat shock protein recognize stressed macrophages.
Science. 1989 Sep 8;245(4922):1112-5 PMID: 2788923
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6115-9 PMID: 8100999
Lymphocytes bearing the gamma delta T-cell receptor in acute toxoplasmosis.
Immunology. 1992 Aug;76(4):668-70 PMID: 1398756
SCID mouse models of acute and relapsing chronic Toxoplasma gondii infections.
Infect Immun. 1992 Sep;60(9):3719-24 PMID: 1500181
Gamma/delta T lymphocytes and heat shock proteins.
Curr Top Microbiol Immunol. 1991;167:191-207 PMID: 2055096
Immune response to Toxoplasma gondii--analysis of suppressor T cells in a patient with symptomatic acute toxoplasmosis.
J Parasitol. 1987 Oct;73(5):954-61 PMID: 2958613
Heat shock proteins defend against intracellular pathogens: a non-immunological basis for self/non-self discrimination?
J Theor Biol. 1985 Aug 7;115(3):471-3 PMID: 4033170
Response to treatment for an intracellular infection in a T cell-deficient host: toxoplasmosis in nude mice.
J Infect Dis. 1993 May;167(5):1173-7 PMID: 8486951
Human gamma delta+ T cells respond to mycobacterial heat-shock protein.
Nature. 1989 Jul 27;340(6231):309-12 PMID: 2473405
Inflammation activates self hsp60-specific T cells.
Eur J Immunol. 1993 Jan;23(1):33-8 PMID: 7678230
Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection.
Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3155-8 PMID: 1557424
Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.
J Exp Med. 1991 Feb 1;173(2):471-81 PMID: 1824857
A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family.
J Exp Med. 1989 Dec 1;170(6):1799-809 PMID: 2584924
Heat shock proteins and inflammation.
Curr Top Microbiol Immunol. 1991;167:93-105 PMID: 2055101
The heat-shock response.
Annu Rev Biochem. 1986;55:1151-91 PMID: 2427013
Cytokine production by T lymphocytes bearing the gamma-delta T cell antigen receptor.
Chem Immunol. 1992;53:32-46 PMID: 1534234
Heat shock genes: regulatory role for differentiation in parasitic protozoa.
Science. 1985 Jun 21;228(4706):1443-6 PMID: 4012301
Gamma/delta cells.
Annu Rev Immunol. 1993;11:637-85 PMID: 8476575
Role of L3T4+ and Lyt-2+ T cell subsets in protective immune responses of mice against infection with a low or high virulent strain of Toxoplasma gondii.
Microbiol Immunol. 1991;35(3):215-22 PMID: 1870439
Gamma delta T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii.
J Immunol. 1995 Jul 1;155(1):244-51 PMID: 7602101
The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes.
J Exp Med. 1988 Nov 1;168(5):1947-52 PMID: 2903217
Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis.
J Clin Microbiol. 1992 Mar;30(3):729-31 PMID: 1532399

Article Info

Journal

Immunologic research

Abbr.

Immunol Res

ISSN

0257-277X

DOI

10.1007/BF02918253

Published

1996-00-00

Pages

258-64

Language

English

Region

United States

NLM ID

8611087

Subset

External Links

PubMed source DOI: 10.1007/BF02918253 View journal details

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Contribution of 65-kDa heat shock protein induced by gamma and delta T cells to protection against Toxoplasma gondii infection.

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