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PMID: 3132709 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Stress proteins are immune targets in leprosy and tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 12 ·1988-06-00 ·Pages 4267-70

Young D, Lathigra R, Hendrix R, Sweetser D, Young RA

Abstract

To understand the immune response to infection by tuberculosis and leprosy bacilli and to develop improved vaccines, the nature of antigens that are involved in humoral and cell-mediated immunity was investigated. We have determined that five immunodominant protein antigens under study are homologues of stress proteins. This finding and observations with other pathogens suggest that infectious agents may respond to the host environment by producing stress proteins and that these proteins can be important immune targets. We postulate that abundant and highly conserved stress proteins may have "immunoprophylactic" potential for a broad spectrum of human pathogens.

MeSH Terms
Amino Acid Sequence Antigens, Bacterial/genetics Cloning, Molecular Cross Reactions Escherichia coli/genetics Genes Genes, Bacterial Heat-Shock Proteins/genetics,immunology Humans Leprosy/immunology Molecular Sequence Data Mycobacterium leprae/genetics,immunology Mycobacterium tuberculosis/genetics,immunology Tuberculosis/immunology
Chemicals
Antigens, Bacterial Heat-Shock Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Young D
Medical Research Council Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, United Kingdom.
Lathigra R
Hendrix R
Sweetser D
Young R A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.12.4267
Published
1988-06-00
Pages
4267-70
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC280408
Subset
IM
Grants
NIAID NIH HHS · AI23545 · United States
Databases
GENBANK
J03838, J03840
External Links
PubMed source DOI: 10.1073/pnas.85.12.4267 PMC Full Text View journal details
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