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PMID: 3534881 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 21 ·1986-11-00 ·Pages 8059-63

Morgan RW, Christman MF, Jacobson FS, Storz G, Ames BN

Abstract

Hydrogen peroxide treatment induces the synthesis of 30 proteins in Salmonella typhimurium. Five of these proteins are also induced by heat shock, including the highly conserved DnaK protein. The induction of one of these five proteins by heat shock is dependent on oxyR, a positive regulator of hydrogen peroxide-inducible genes, while the induction of the other four by heat shock is oxyR independent. Five of the 30 hydrogen peroxide-inducible proteins have been identified, and their structural genes have been mapped. Other stresses such as nalidixic acid, ethanol, or cumene hydroperoxide treatment also induce subsets of the 30 hydrogen peroxide-inducible proteins as well as additional proteins. Hydrogen peroxide-inducible proteins are shown to be largely different from those proteins induced by aerobiosis. In addition, the expression of the katG (catalase) gene is shown to be regulated by oxyR at the level of mRNA.

MeSH Terms
Adaptation, Physiological Aerobiosis Cadmium/pharmacology Cadmium Chloride Catalase/genetics Escherichia coli/metabolism Gene Expression Regulation/drug effects Genes, Regulator Heat-Shock Proteins/biosynthesis Hydrogen Peroxide/pharmacology Salmonella typhimurium/metabolism Transcription, Genetic
Chemicals
Heat-Shock Proteins Cadmium Hydrogen Peroxide Catalase Cadmium Chloride
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Morgan R W
Christman M F
Jacobson F S
Storz G
Ames B N
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34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.21.8059
Published
1986-11-00
Pages
8059-63
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC386866
Subset
IM
Grants
NIEHS NIH HHS · ES01896 · United States
NIGMS NIH HHS · GM08864 · United States
NIGMS NIH HHS · GM19993 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.21.8059 PMC Full Text View journal details
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