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PMID: 6337115 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Escherichia coli xth mutants are hypersensitive to hydrogen peroxide.

Journal of bacteriology ·Vol. 153 ·No. 2 ·1983-02-00 ·Pages 1079-82

Demple B, Halbrook J, Linn S

Abstract

Escherichia coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-induced lethality and the in vivo role of exonuclease III.

MeSH Terms
Catalase/metabolism Escherichia coli/drug effects,enzymology,genetics Exodeoxyribonucleases/physiology Hydrogen Peroxide/pharmacology Mutation Phenotype
Chemicals
Hydrogen Peroxide Catalase Exodeoxyribonucleases exodeoxyribonuclease III
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Demple B
Halbrook J
Linn S
References (25)
25 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.153.2.1079-1082.1983
Published
1983-02-00
Pages
1079-82
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC221738
Subset
IM
Grants
NIEHS NIH HHS · ES07075 · United States
NIGMS NIH HHS · GM 19020 · United States
External Links
PubMed source DOI: 10.1128/jb.153.2.1079-1082.1983 PMC Full Text View journal details
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