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PMID: 6576347 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Chromosomal assignment of a family of human oncogenes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 14 ·1983-07-00 ·Pages 4460-3

Ryan J, Barker PE, Shimizu K, Wigler M, Ruddle FH

Abstract

A family of human transforming genes, previously shown to share homology with the ras family of viral oncogenes, maps to three different human chromosomes. A well-characterized mouse-human hybrid cell panel, combined with Southern blotting, was used in this study. The transforming gene of the T24 bladder carcinoma cell line maps to human chromosome 11. An oncogene isolated from the lung carcinoma cell line SK-Calu-1 maps to human chromosome 12. The third ras-related gene, cloned from SK-N-SH, a neuroblastoma cell line, maps to human chromosome 1.

MeSH Terms
Animals Cell Line Cell Transformation, Neoplastic Chromosomes, Human/physiology Genes, Viral Humans Hybrid Cells Lung Neoplasms/genetics Mice Neuroblastoma/genetics Nucleic Acid Hybridization Oncogenes Retroviridae/genetics
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ryan J
Barker P E
Shimizu K
Wigler M
Ruddle F H
References (41)
41 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.14.4460
Published
1983-07-00
Pages
4460-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC384058
Subset
IM
Grants
NICHD NIH HHS · 5T32-HD07149-03 · United States
NIGMS NIH HHS · GM09966 · United States
External Links
PubMed source DOI: 10.1073/pnas.80.14.4460 PMC Full Text View journal details
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