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PMID: 6293057 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Chromosomal assignment of the endogenous proto-oncogene C-abl.

Science (New York, N.Y.) ·Vol. 218 ·No. 4579 ·1982-12-24 ·Pages 1317-9

Goff SP, D'Eustachio P, Ruddle FH, Baltimore D

Abstract

Abelson murine leukemia virus (A-MuLV) is a replication-defective retrovirus that transforms lymphocytes of the B-cell lineage. This virus is a recombinant between the parental Moloney murine leukemia virus and a cellular gene termed C-abl. By analysis of a series of mouse x Chinese hamster hybrid celllines containing various mouse chromosomes, we have mapped the C-abl gene to mouse chromosome 2.

MeSH Terms

Abelson murine leukemia virus/genetics Animals B-Lymphocytes Cell Transformation, Viral Chromosome Mapping Cricetinae Cricetulus Hybrid Cells/analysis Leukemia Virus, Murine/genetics Mice Oncogenes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Goff S P

D'Eustachio P

Ruddle F H

Baltimore D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6293057

Published

1982-12-24

Pages

1317-9

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NCI NIH HHS · CA-14051 · United States

NIGMS NIH HHS · GM-09966 · United States

External Links

PubMed source DOI: 10.1126/science.6293057 View journal details

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Chromosomal assignment of the endogenous proto-oncogene C-abl.

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