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PMID: 6283357 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.

Nature ·Vol. 297 ·No. 5866 ·1982-06-10 ·Pages 474-8

Parada LF, Tabin CJ, Shih C, Weinberg RA

Abstract

Examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma (EJ) oncogene is homologous to the Harvey sarcoma virus oncogene (ras). Structural analysis limits the region of homology to a 3.0-kilobase SacI fragment of the EJ oncogene. Both EJ and ras DNA probes detect similar transcripts in transfectants derived from bladder carcinoma cell lines.

MeSH Terms

Animals Base Sequence Cell Line Cell Transformation, Neoplastic DNA Restriction Enzymes DNA, Neoplasm/genetics DNA, Viral/genetics Genes Genes, Viral Humans Mice Nucleic Acid Hybridization Oncogenic Viruses/genetics Sarcoma Viruses, Murine/genetics Species Specificity Transcription, Genetic Urinary Bladder Neoplasms/genetics

Chemicals

DNA, Neoplasm DNA, Viral DNA Restriction Enzymes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Parada L F

Tabin C J

Shih C

Weinberg R A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/297474a0

Published

1982-06-10

Pages

474-8

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NCI NIH HHS · CA17537 · United States

NCI NIH HHS · CA26717 · United States

External Links

PubMed source DOI: 10.1038/297474a0 View journal details

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Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.

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