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PMID: 6290897 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mechanism of activation of a human oncogene.

Nature ·Vol. 300 ·No. 5888 ·1982-11-11 ·Pages 143-9

Tabin CJ, Bradley SM, Bargmann CI, Weinberg RA, Papageorge AG, Scolnick EM, Dhar R, Lowy DR, Chang EH

Abstract

The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein.

MeSH Terms

Base Sequence Cell Line Cell Transformation, Neoplastic Cloning, Molecular DNA Restriction Enzymes/metabolism Gene Expression Regulation Humans Molecular Weight Mutation Neoplasm Proteins/biosynthesis Oncogenes Proto-Oncogene Mas RNA, Neoplasm/analysis Transfection Urinary Bladder Neoplasms/genetics

Chemicals

MAS1 protein, human Neoplasm Proteins Proto-Oncogene Mas RNA, Neoplasm DNA Restriction Enzymes

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Tabin C J

Bradley S M

Bargmann C I

Weinberg R A

Papageorge A G

Scolnick E M

Dhar R

Lowy D R

Chang E H

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/300143a0

Published

1982-11-11

Pages

143-9

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NCI NIH HHS · CA17537 · United States

NCI NIH HHS · CA26717 · United States

NCI NIH HHS · CA31649 · United States

Databases

GENBANK

J00206, J00276, J00277, K00954

External Links

PubMed source DOI: 10.1038/300143a0 View journal details

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Mechanism of activation of a human oncogene.

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