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PMID: 6320193 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 2 ·1984-01-00 ·Pages 525-9

Sakaguchi AY, Lalley PA, Zabel BU, Ellis RW, Scolnick EM, Naylor SL

Abstract

Molecular probes for the oncogenes of Rous sarcoma virus (v-src), avian myeloblastosis virus (v-myb), Kirsten murine sarcoma virus (v-Ki-ras), and Harvey murine sarcoma virus (v-Ha-ras) were hybridized to the DNA from mouse-Chinese hamster somatic cell hybrids. The v-src, v-myb, v-Ki-ras, and v-Ha-ras genes each detected one or a few homologous mouse DNA fragments whose segregation was analyzed in cell hybrids. Mouse cellular homologs c-src, c-Ki-ras, c-Ha-ras, and c-myb segregated concordantly with chromosomes 2, 6, 7, and 10, respectively. Comparison with the known locations of human c-src (chromosome 20) and human c-Ha-ras1 (chromosome 11 short arm) suggests that the human and mouse homologs of these two viral oncogenes reside in conserved linkage groups. The c-Ki-ras gene on mouse chromosome 6 might reside also in a conserved linkage group, along with glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase. However, direct confirmation of this suggestion must await a demonstration that c-Ki-ras on mouse chromosome 6 is homologous to c-Ki-ras2 on the short arm of human chromosome 12.

MeSH Terms
Animals Avian Myeloblastosis Virus/genetics Avian Sarcoma Viruses/genetics Chromosome Mapping Cricetinae Genes Genes, Viral Genetic Linkage Hybrid Cells Kirsten murine sarcoma virus/genetics Mice Oncogenes Sarcoma Viruses, Murine/genetics
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Sakaguchi A Y
Lalley P A
Zabel B U
Ellis R W
Scolnick E M
Naylor S L
References (53)
53 references, click to expand
  1. Structure and transcription of the cellular homolog (c-myb) of the avian myeloblastosis virus transforming gene (v-myb).
    J Virol. 1983 Apr;46(1):212-20 PMID: 6298458
  2. Cancer genes come of age.
    Cell. 1983 Apr;32(4):1018-20 PMID: 6340833
  3. Three loci related to the src oncogene and tyrosine-specific protein kinase activity in Drosophila.
    Nature. 1983 Apr 28;302(5911):837-9 PMID: 6405280
  4. DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas.
    Science. 1983 May 20;220(4599):795-8 PMID: 6687762
  5. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.
    Nature. 1983 Jun 9-15;303(5917):497-501 PMID: 6304530
  6. Human and mouse cellular myc protooncogenes reside on chromosomes involved in numerical and structural aberrations in cancer.
    Somatic Cell Genet. 1983 May;9(3):391-405 PMID: 6857448
  7. Retroviruses and cancer genes.
    Adv Cancer Res. 1982;37:1-32 PMID: 6763842
  8. Genetic mapping of the mouse oncogenes c-Ha-ras-1 and c-fes to chromosome 7.
    J Virol. 1983 Jul;47(1):217-20 PMID: 6864883
  9. Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15.
    Science. 1983 Aug 26;221(4613):867-9 PMID: 6308764
  10. A sequence homologous to Rous sarcoma virus v-src Is on human chromosome 20.
    Prog Nucleic Acid Res Mol Biol. 1983;29:279-83 PMID: 6320292
  11. A system of nomenclature for band patterns of mouse chromosomes.
    Chromosoma. 1973;41(2):145-58 PMID: 4120886
  12. Chromosomal deletion and retinoblastoma.
    N Engl J Med. 1976 Nov 11;295(20):1120-3 PMID: 980006
  13. Sporadic bilateral retinoblastoma and 13q- chromosomal deletion.
    Med Pediatr Oncol. 1976;2(4):379-85 PMID: 1004381
  14. Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus.
    Nature. 1982 May 20;297(5863):205-8 PMID: 6281656
  15. Identification of the constant chromosome regions involved in human hematologic malignant disease.
    Science. 1982 May 14;216(4547):749-51 PMID: 7079737
  16. Chromosomal localization of human cellular homologues of two viral oncogenes.
    Nature. 1982 Oct 21;299(5885):747-9 PMID: 7121606
  17. Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses.
    Proc Natl Acad Sci U S A. 1982 Aug;79(16):4848-52 PMID: 6289320
  18. Mechanism of activation of a human oncogene.
    Nature. 1982 Nov 11;300(5888):143-9 PMID: 6290897
  19. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.
    Nature. 1982 Nov 11;300(5888):149-52 PMID: 7133135
  20. Chromosomal aberrations observed in 52 mouse myeloid leukemias.
    Cancer Res. 1983 Jan;43(1):367-73 PMID: 6571708
  21. Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses.
    Cell. 1982 Oct;30(3):787-95 PMID: 6291784
  22. DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an EcoRI fragment of recovered avian sarcoma virus which codes for gp37 and pp60src.
    J Virol. 1982 Oct;44(1):1-11 PMID: 6292477
  23. Chromosomal localization of the Moloney sarcoma virus mouse cellular (c-mos) sequence.
    J Virol. 1982 Nov;44(2):752-4 PMID: 7143580
  24. Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element.
    Nature. 1982 Dec 16;300(5893):607-11 PMID: 6292737
  25. Chromosomal assignment of the endogenous proto-oncogene C-abl.
    Science. 1982 Dec 24;218(4579):1317-9 PMID: 6293057
  26. Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas.
    Science. 1982 Dec 24;218(4579):1319-21 PMID: 7146913
  27. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia.
    Nature. 1982 Dec 23;300(5894):765-7 PMID: 6960256
  28. Oncogene from human EJ bladder carcinoma is located on the short arm of chromosome 11.
    Science. 1983 Feb 4;219(4584):498-501 PMID: 6297001
  29. Human c-Ki-ras2 proto-oncogene on chromosome 12.
    Science. 1983 Mar 4;219(4588):1081-3 PMID: 6823569
  30. Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas.
    Cell. 1982 Dec;31(2 Pt 1):443-52 PMID: 6819085
  31. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene.
    Cell. 1982 Dec;31(2 Pt 1):453-63 PMID: 6297766
  32. Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men.
    Cell. 1983 Feb;32(2):311-5 PMID: 6402307
  33. Analysis of restriction fragments of T7 DNA and determination of molecular weights by electrophoresis in neutral and alkaline gels.
    J Mol Biol. 1977 Feb 15;110(1):119-46 PMID: 845942
  34. Chinese hamster X mouse hybrid cells segregating mouse chromosomes and isozymes.
    Somatic Cell Genet. 1975 Oct;1(4):355-69 PMID: 1235911
  35. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
    J Mol Biol. 1977 Jun 15;113(1):237-51 PMID: 881736
  36. Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2.
    Cytogenet Cell Genet. 1977;19(2-3):57-84 PMID: 198184
  37. Chromosomal imbalance in the Aniridia-Wilms' tumor association: 11p interstitial deletion.
    Pediatrics. 1978 Apr;61(4):604-10 PMID: 208044
  38. Homologous genes for enolase, phosphogluconate dehydrogenase, phosphoglucomutase, and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome 1p.
    Proc Natl Acad Sci U S A. 1978 May;75(5):2382-6 PMID: 209463
  39. Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.
    Proc Natl Acad Sci U S A. 1978 Sep;75(9):4102-6 PMID: 212733
  40. Chromosomal evolution in primates: tentative phylogeny from Microcebus murinus (Prosimian) to man.
    Hum Genet. 1979 May 10;48(3):251-314 PMID: 112030
  41. Hereditary renal-cell carcinoma associated with a chromosomal translocation.
    N Engl J Med. 1979 Sep 13;301(11):592-5 PMID: 470981
  42. Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation.
    Nature. 1979 Oct 11;281(5731):452-5 PMID: 226888
  43. Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus.
    J Virol. 1980 Nov;36(2):408-20 PMID: 6253666
  44. Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product.
    Nature. 1980 Sep 18;287(5779):198-203 PMID: 6253794
  45. Molecular cloning and characterization of avian sarcoma virus circular DNA molecules.
    J Virol. 1980 Oct;36(1):50-61 PMID: 6255214
  46. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.
    Nature. 1981 Aug 6;292(5823):506-11 PMID: 6265801
  47. Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3328-32 PMID: 6267583
  48. The role of gene dosage and genetic transpositions in carcinogenesis.
    Nature. 1981 Nov 26;294(5839):313-8 PMID: 7312030
  49. DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1981 Nov;78(11):6789-92 PMID: 6796966
  50. Vertebrate DNAs contain nucleotide sequences related to the transforming gene of avian myeloblastosis virus.
    J Virol. 1981 Nov;40(2):450-5 PMID: 6275098
  51. Proposal for naming host cell-derived inserts in retrovirus genomes.
    J Virol. 1981 Dec;40(3):953-7 PMID: 7321107
  52. Amplification and rearrangement of onc genes in mammalian species.
    Nature. 1982 Mar 25;296(5855):361-3 PMID: 7063034
  53. Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein.
    Cancer Res. 1982 Jun;42(6):2429-33 PMID: 6280857
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.2.525
Published
1984-01-00
Pages
525-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC344711
Subset
IM
Grants
NCI NIH HHS · CA16056 · United States
NIGMS NIH HHS · GM20454 · United States
External Links
PubMed source DOI: 10.1073/pnas.81.2.525 PMC Full Text View journal details
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