Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15.

Science (New York, N.Y.) ·Vol. 221 ·No. 4613 ·1983-08-26 ·Pages 867-9

Kozak CA, Sears JF, Hoggan MD

Abstract

The mouse homolog (c-sis) of the transforming gene of the simian sarcoma virus was mapped to chromosome 15 by the Southern blot analysis of DNA's from hamster-mouse somatic cell hybrids. Alterations in c-sis expression may thus play a role in the various murine neoplastic diseases characterized by rearrangements or duplications of chromosome 15.

MeSH Terms

Animals Chromosome Aberrations/genetics Chromosome Disorders Chromosome Mapping Leukemia, Experimental/genetics Mice Nucleic Acid Hybridization Oncogenes Retroviridae/genetics Sarcoma Virus, Woolly Monkey/genetics

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kozak C A

Sears J F

Hoggan M D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6308764

Published

1983-08-26

Pages

867-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.6308764 View journal details

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Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15.

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