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PMID: 26888746 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.

The EMBO journal ·Vol. 35 ·No. 6 ·2016-03-15 ·Pages 561-79

Marat AL, Haucke V

Abstract

Phosphoinositides (PIs) form a minor class of phospholipids with crucial functions in cell physiology, ranging from cell signalling and motility to a role as signposts of compartmental membrane identity. Phosphatidylinositol 3-phosphates are present at the plasma membrane and within the endolysosomal system, where they serve as key regulators of both cell signalling and of intracellular membrane traffic. Here, we provide an overview of the metabolic pathways that regulate cellular synthesis of PI 3-phosphates at distinct intracellular sites and discuss the mechanisms by which these lipids regulate cell signalling and membrane traffic. Finally, we provide a framework for how PI 3-phosphate metabolism is integrated into the cellular network.

Keywords
autophagy endolysosomal system membrane traffic phosphatidylinositol 3‐phosphate signalling
MeSH Terms
Cell Membrane/metabolism Cell Physiological Phenomena Gene Regulatory Networks Intracellular Membranes/metabolism Metabolic Networks and Pathways Phosphatidylinositol Phosphates/metabolism Signal Transduction
Chemicals
Phosphatidylinositol Phosphates phosphatidylinositol 3-phosphate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Marat Andrea L
Leibniz Institut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Haucke Volker
Leibniz Institut für Molekulare Pharmakologie (FMP), Berlin, Germany haucke@fmp-berlin.de.
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
1460-2075
DOI
10.15252/embj.201593564
Email
haucke@fmp-berlin.de
Published
2016-03-15
Epub
2016-00-17
Pages
561-79
Language
English
Region
England
NLM ID
8208664
PMCID
PMC4801949
Subset
IM
External Links
PubMed source DOI: 10.15252/embj.201593564 PMC Full Text View journal details
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