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PMID: 20549473 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

PI3K: from the bench to the clinic and back.

Current topics in microbiology and immunology ·Vol. 347 ·2010-00-00 ·Pages 1-19

Vanhaesebroeck B, Vogt PK, Rommel C

Abstract

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here, we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.PI3K has become a very intense area of research, with over 2,000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target. PI3K will most likely be no exception. Below, we describe some of these early "surprises" and how these inform and shape basic science investigations.

MeSH Terms
Animals Humans Phosphatidylinositol 3-Kinases/physiology Phosphoinositide-3 Kinase Inhibitors Protein Kinase Inhibitors/therapeutic use Signal Transduction
Chemicals
Phosphoinositide-3 Kinase Inhibitors Protein Kinase Inhibitors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Vanhaesebroeck Bart
University of London, London, EC1M 6BQ, UK. bart.vanh@qmul.ac.uk
Vogt Peter K
Rommel Christian
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Article Info
Journal
Current topics in microbiology and immunology
Abbr.
Curr Top Microbiol Immunol
ISSN
0070-217X
DOI
10.1007/82_2010_65
Email
bart.vanh@qmul.ac.uk
Published
2010-00-00
Pages
1-19
Language
English
Region
Germany
NLM ID
0110513
PMCID
PMC2954281
Subset
IM
Grants
NCI NIH HHS · R01 CA115521-03 · United States
Biotechnology and Biological Sciences Research Council · BB/C505659/1 · United Kingdom
NCI NIH HHS · R01 CA078230-11 · United States
Biotechnology and Biological Sciences Research Council · BB/C505659/2 · United Kingdom
NCI NIH HHS · R01 CA107094-01A1 · United States
NCI NIH HHS · R01 CA115521-04 · United States
NCI NIH HHS · R01 CA107094-04 · United States
Cancer Research UK · United Kingdom
NCI NIH HHS · R01 CA115521-02 · United States
NCI NIH HHS · R01 CA078230-10 · United States
NCI NIH HHS · R01 CA115521 · United States
NCI NIH HHS · R01 CA107094-05 · United States
NCI NIH HHS · R01 CA107094 · United States
NCI NIH HHS · R01 CA078230 · United States
NCI NIH HHS · R01 CA107094-02 · United States
NCI NIH HHS · P01 CA078045-10 · United States
NCI NIH HHS · P01 CA078045-07 · United States
NCI NIH HHS · R01 CA115521-01 · United States
NCI NIH HHS · R01 CA078230-07 · United States
Medical Research Council · United Kingdom
NCI NIH HHS · P01 CA078045-08 · United States
NCI NIH HHS · R01 CA078230-08 · United States
NCI NIH HHS · P01 CA078045 · United States
NCI NIH HHS · R01 CA107094-03 · United States
NCI NIH HHS · R01 CA078230-12 · United States
NCI NIH HHS · P01 CA078045-06A1 · United States
NCI NIH HHS · R01 CA078230-09 · United States
NCI NIH HHS · P01 CA078045-09 · United States
External Links
PubMed source DOI: 10.1007/82_2010_65 PMC Full Text View journal details
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