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PMID: 22281700 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Phosphoinositides and vesicular membrane traffic.

Biochimica et biophysica acta ·Vol. 1821 ·No. 8 ·2012-08-00 ·Pages 1104-13

Mayinger P

Abstract

Phosphoinositide lipids were initially discovered as precursors for specific second messengers involved in signal transduction, but have now taken the center stage in controlling many essential processes at virtually every cellular membrane. In particular, phosphoinositides play a critical role in regulating membrane dynamics and vesicular transport. The unique distribution of certain phosphoinositides at specific intracellular membranes makes these molecules uniquely suited to direct organelle-specific trafficking reactions. In this regulatory role, phosphoinositides cooperate specifically with small GTPases from the Arf and Rab families. This review will summarize recent progress in the study of phosphoinositides in membrane trafficking and organellar organization and highlight the particular relevance of these signaling pathways in disease. This article is part of a Special Issue entitled Lipids and Vesicular Transport.

MeSH Terms
ADP-Ribosylation Factors/metabolism Animals Cell Membrane/metabolism Endocytosis Golgi Apparatus/metabolism Humans Intracellular Membranes/metabolism Lipid Metabolism Phosphatidylinositols/metabolism Phosphotransferases/metabolism Protein Transport Signal Transduction Transport Vesicles/metabolism rab GTP-Binding Proteins/metabolism
Chemicals
Phosphatidylinositols Phosphotransferases ADP-Ribosylation Factors rab GTP-Binding Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Mayinger Peter
Division of Nephrology & Hypertension and Department of Cell & Developmental Biology, Oregon Health & Science University, Portland, OR 97239, USA. mayinger@ohsu.edu
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbalip.2012.01.002
Email
mayinger@ohsu.edu
Published
2012-08-00
Epub
2012-00-14
Pages
1104-13
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC3340507
Subset
IM
Grants
NIGMS NIH HHS · R01 GM084088-02 · United States
NIGMS NIH HHS · GM071569 · United States
NIGMS NIH HHS · R01 GM071569-05 · United States
NIGMS NIH HHS · GM084088 · United States
NIGMS NIH HHS · R01 GM071569 · United States
NIGMS NIH HHS · R01 GM084088 · United States
External Links
PubMed source DOI: 10.1016/j.bbalip.2012.01.002 PMC Full Text
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