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PMID: 19914387 Published · ppublish English Journal Article Review

SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting.

Seminars in cell & developmental biology ·Vol. 21 ·No. 4 ·2010-06-00 ·Pages 371-80

van Weering JR, Verkade P, Cullen PJ

Abstract

The endocytic network is morphologically characterized by a wide variety of membrane bound compartments that are able to undergo dynamic re-modeling through tubular and vesicular structures. The precise molecular mechanisms governing such re-modeling, and the events that co-ordinated this with the major role of endosomes, cargo sorting, remain unclear. That said, recent work on a protein family of sorting nexins (SNX) - especially a subfamily of SNX that contain a BAR domain (SNX-BARs) - has begun to shed some much needed light on these issues and in particular the process of tubular-based endosomal sorting. SNX-BARs are evolutionary conserved in endosomal protein complexes such as retromer, where they co-ordinate membrane deformation with cargo selection. Furthermore a central theme emerges of SNX-BARs linking the forming membrane carrier to cytoskeletal elements for transport through motor proteins such as dynein. By studying these SNX-BARs, we are gaining an increasingly detailed appreciation of the mechanistic basis of endosomal sorting and how this highly dynamic process functions in health and disease.

MeSH Terms
Animals Biological Transport/physiology Carrier Proteins/chemistry,classification,genetics,metabolism Cell Membrane/metabolism,ultrastructure Clathrin/metabolism Endocytosis/physiology Endosomes/metabolism Humans Models, Molecular Molecular Motor Proteins/chemistry,metabolism Phosphatidylinositols/metabolism Phylogeny Protein Conformation Protein Isoforms/genetics,metabolism Sorting Nexins Vesicular Transport Proteins/chemistry,classification,genetics,metabolism trans-Golgi Network/metabolism
Chemicals
Carrier Proteins Clathrin Molecular Motor Proteins Phosphatidylinositols Protein Isoforms Sorting Nexins Vesicular Transport Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
van Weering Jan R T
The Henry Wellcome Integrated Signalling Laboratories, Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom.
Verkade Paul
Cullen Peter J
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Article Info
Journal
Seminars in cell & developmental biology
Abbr.
Semin Cell Dev Biol
ISSN
1096-3634
DOI
10.1016/j.semcdb.2009.11.009
Published
2010-06-00
Epub
2009-00-13
Pages
371-80
Language
English
Region
England
NLM ID
9607332
PMCID
PMC4052211
Subset
IM
Grants
Wellcome Trust · 085743 · United Kingdom
Wellcome Trust · 089928 · United Kingdom
External Links
PubMed source DOI: 10.1016/j.semcdb.2009.11.009 PMC Full Text View journal details
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