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PMID: 19379681 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The BAR domain superfamily: membrane-molding macromolecules.

Cell ·Vol. 137 ·No. 2 ·2009-04-17 ·Pages 191-6

Frost A, Unger VM, De Camilli P

Abstract

Membrane-shaping proteins of the BAR domain superfamily are determinants of organelle biogenesis, membrane trafficking, cell division, and cell migration. An upsurge of research now reveals new principles of BAR domain-mediated membrane remodeling, enhancing our understanding of membrane curvature-mediated information processing.

MeSH Terms
Animals Cell Membrane/chemistry,ultrastructure Cytoskeleton/metabolism GTP Phosphohydrolases/metabolism Humans Membrane Proteins/chemistry,metabolism,ultrastructure Protein Structure, Tertiary
Chemicals
Membrane Proteins GTP Phosphohydrolases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Frost Adam
Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT 06510, USA.
Unger Vinzenz M
De Camilli Pietro
References (44)
44 references, click to expand
  1. Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle.
    Science. 2002 Aug 16;297(5584):1193-6 PMID: 12183633
  2. An in vivo map of the yeast protein interactome.
    Science. 2008 Jun 13;320(5882):1465-70 PMID: 18467557
  3. Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast.
    J Cell Biol. 2006 Jul 31;174(3):391-402 PMID: 16864655
  4. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton.
    Nat Rev Mol Cell Biol. 2007 Jan;8(1):37-48 PMID: 17183359
  5. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis.
    Mol Cell Biol. 2005 Nov;25(21):9369-82 PMID: 16227588
  6. Mechanism of endophilin N-BAR domain-mediated membrane curvature.
    EMBO J. 2006 Jun 21;25(12):2898-910 PMID: 16763559
  7. Endosomal sorting and signalling: an emerging role for sorting nexins.
    Nat Rev Mol Cell Biol. 2008 Jul;9(7):574-82 PMID: 18523436
  8. BAR domains as sensors of membrane curvature: the amphiphysin BAR structure.
    Science. 2004 Jan 23;303(5657):495-9 PMID: 14645856
  9. F-BAR proteins join the BAR family fold.
    Structure. 2007 Jul;15(7):751-3 PMID: 17637334
  10. A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.
    Science. 2007 Apr 27;316(5824):570-4 PMID: 17463283
  11. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis.
    Cell. 2007 May 18;129(4):761-72 PMID: 17512409
  12. Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle.
    J Cell Biol. 1997 Jun 16;137(6):1355-67 PMID: 9182667
  13. The GTPase-activating protein GRAF1 regulates the CLIC/GEEC endocytic pathway.
    Curr Biol. 2008 Nov 25;18(22):1802-8 PMID: 19036340
  14. Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila.
    Genes Dev. 2001 Nov 15;15(22):2967-79 PMID: 11711432
  15. SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis.
    Dev Cell. 2007 Jul;13(1):43-56 PMID: 17609109
  16. Implication of amphiphysin 1 and dynamin 2 in tubulobulbar complex formation and spermatid release.
    Cell Struct Funct. 2007;32(2):101-13 PMID: 17785912
  17. Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins.
    Dev Cell. 2005 Dec;9(6):791-804 PMID: 16326391
  18. Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution.
    J Cell Biol. 1998 Dec 28;143(7):1947-60 PMID: 9864366
  19. Pathways of clathrin-independent endocytosis.
    Nat Rev Mol Cell Biol. 2007 Aug;8(8):603-12 PMID: 17609668
  20. Retromer.
    Curr Opin Cell Biol. 2008 Aug;20(4):427-36 PMID: 18472259
  21. BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature.
    Biochim Biophys Acta. 2006 Aug;1761(8):897-912 PMID: 16938488
  22. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
    Cell. 2004 Feb 6;116(3):445-56 PMID: 15016378
  23. Syndapin promotes formation of a postsynaptic membrane system in Drosophila.
    Mol Biol Cell. 2009 Apr;20(8):2254-64 PMID: 19244343
  24. The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
    Nature. 2001 May 10;411(6834):215-9 PMID: 11346801
  25. Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation.
    Biophys J. 2007 May 15;92(10):3595-602 PMID: 17325001
  26. Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis.
    Nat Cell Biol. 1999 May;1(1):33-9 PMID: 10559861
  27. Dynamics of cytoplasmic organelles in the cell cycle of the fission yeast Schizosaccharomyces pombe: three-dimensional reconstruction from serial sections.
    J Cell Sci. 1989 Dec;94 ( Pt 4):647-56 PMID: 2630561
  28. Endophilin B1 is required for the maintenance of mitochondrial morphology.
    J Cell Biol. 2004 Sep 27;166(7):1027-39 PMID: 15452144
  29. Molecular mechanisms of membrane deformation by I-BAR domain proteins.
    Curr Biol. 2009 Jan 27;19(2):95-107 PMID: 19150238
  30. Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy.
    Nat Genet. 2007 Sep;39(9):1134-9 PMID: 17676042
  31. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.
    Nature. 2000 Dec 7;408(6813):732-5 PMID: 11130076
  32. Hierarchical regulation of WASP/WAVE proteins.
    Mol Cell. 2008 Nov 7;32(3):426-38 PMID: 18995840
  33. PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase.
    J Cell Biol. 1997 Aug 25;138(4):845-60 PMID: 9265651
  34. Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth.
    J Neurosci. 2008 Aug 13;28(33):8316-25 PMID: 18701694
  35. A modular design for the clathrin- and actin-mediated endocytosis machinery.
    Cell. 2005 Oct 21;123(2):305-20 PMID: 16239147
  36. Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism.
    J Cell Biol. 2007 Mar 26;176(7):953-64 PMID: 17371834
  37. Structural basis of membrane invagination by F-BAR domains.
    Cell. 2008 Mar 7;132(5):807-17 PMID: 18329367
  38. The BAR-domain family of proteins: a case of bending and binding?
    EMBO Rep. 2004 Mar;5(3):250-5 PMID: 14993925
  39. Initial steps in receptor-mediated endocytosis. The influence of temperature on the shape and distribution of plasma membrane clathrin-coated pits in cultured mammalian cells.
    Exp Cell Res. 1984 Jun;152(2):558-64 PMID: 6144562
  40. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.
    Nat Cell Biol. 2007 Oct;9(10):1142-51 PMID: 17891140
  41. Generation of high curvature membranes mediated by direct endophilin bilayer interactions.
    J Cell Biol. 2001 Oct 15;155(2):193-200 PMID: 11604418
  42. Parkin mitochondria in the autophagosome.
    J Cell Biol. 2008 Dec 1;183(5):757-9 PMID: 19029341
  43. A functional link between dynamin and the actin cytoskeleton at podosomes.
    J Cell Biol. 2000 Jul 24;150(2):377-89 PMID: 10908579
  44. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.
    Cell. 2004 Jul 23;118(2):203-16 PMID: 15260990
Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2009.04.010
Published
2009-04-17
Pages
191-6
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC4832598
Subset
IM
Grants
NIDA NIH HHS · P30 DA018343 · United States
NIDA NIH HHS · R21 DA024101 · United States
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1016/j.cell.2009.04.010 PMC Full Text View journal details
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