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PMID: 18472259 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Retromer.

Current opinion in cell biology ·Vol. 20 ·No. 4 ·2008-08-00 ·Pages 427-36

Bonifacino JS, Hurley JH

Abstract

The retromer is a heteropentameric complex that associates with the cytosolic face of endosomes and mediates retrograde transport of transmembrane cargo from endosomes to the trans-Golgi network. The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition trimer composed of Vps26, Vps29 and Vps35. The SNX subunits contain PX and BAR domains that allow binding to PI(3)P enriched, highly curved membranes of endosomal vesicles and tubules, while Vps26, Vps29 and Vps35 have arrestin, phosphoesterase and alpha-solenoid folds, respectively. Recent studies have implicated retromer in a broad range of physiological, developmental and pathological processes, underscoring the critical nature of retrograde transport mediated by this complex.

MeSH Terms
Carrier Proteins/metabolism Endosomes/metabolism Humans Protein Transport Sorting Nexins Vesicular Transport Proteins/metabolism trans-Golgi Network/metabolism
Chemicals
Carrier Proteins Sorting Nexins Vesicular Transport Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bonifacino Juan S
Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, Building 18T/Room 101, National Institutes of Health, Bethesda, MD 20892, USA. juan@helix.nih.gov
Hurley James H
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/j.ceb.2008.03.009
Email
juan@helix.nih.gov
Published
2008-08-00
Epub
2008-00-09
Pages
427-36
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2833274
Subset
IM
Grants
Intramural NIH HHS · Z01 HD001607-16 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2008.03.009 PMC Full Text View journal details
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