Home LiteratureArticle Details
PMID: 16139503 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Coincidence detection in phosphoinositide signaling.

Trends in cell biology ·Vol. 15 ·No. 10 ·2005-10-00 ·Pages 540-7

Carlton JG, Cullen PJ

Abstract

Phosphoinositide lipids function as both signaling molecules and as compartment-specific localization signals for phosphoinositide-binding proteins. In recent years, both phosphoinositides and phosphoinositide-binding proteins have been reported to display a restricted, rather than a uniform, distribution across intracellular membranes. Here, we examine recent data documenting the restricted distribution of both phosphoinositides and phosphoinositide-binding proteins and examine how phosphoinositide-binding proteins might engage multiple binding partners to achieve these restricted localizations, effectively acting as detectors of coincident localization signals.

MeSH Terms
Enzyme Activation Lipid Metabolism Lipids/chemistry Membrane Microdomains Models, Molecular Molecular Structure Phosphatidylinositols/chemistry,metabolism Second Messenger Systems/physiology
Chemicals
Lipids Phosphatidylinositols
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Carlton Jez G
Department of Biochemistry, School of Medical Sciences, University of Bristol, UK.
Cullen Peter J
References (72)
72 references, click to expand
  1. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments.
    J Cell Sci. 2001 Nov;114(Pt 22):3991-4000 PMID: 11739631
  2. Multivalent endosome targeting by homodimeric EEA1.
    Mol Cell. 2001 Nov;8(5):947-58 PMID: 11741531
  3. Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization.
    J Biol Chem. 2002 Feb 22;277(8):6073-9 PMID: 11706043
  4. Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1.
    Biochem J. 2002 May 1;363(Pt 3):657-66 PMID: 11964166
  5. Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components.
    Curr Biol. 2002 Apr 30;12(9):695-704 PMID: 12007412
  6. Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy.
    J Biol Chem. 2002 Aug 16;277(33):30198-207 PMID: 12048214
  7. Agonist-induced PIP(2) hydrolysis inhibits cortical actin dynamics: regulation at a global but not at a micrometer scale.
    Mol Biol Cell. 2002 Sep;13(9):3257-67 PMID: 12221130
  8. Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex.
    Mol Biol Cell. 2001 Jul;12(7):2219-28 PMID: 11452015
  9. PI(4,5)P(2) regulation of surface membrane traffic.
    Curr Opin Cell Biol. 2001 Aug;13(4):493-9 PMID: 11454457
  10. PTEN.
    Curr Biol. 2001 Jul 10;11(13):R502 PMID: 11470419
  11. FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes.
    J Cell Sci. 2001 Jun;114(Pt 12):2255-63 PMID: 11493665
  12. New EMBO members' review: actin cytoskeleton regulation through modulation of PI(4,5)P(2) rafts.
    EMBO J. 2001 Aug 15;20(16):4332-6 PMID: 11500359
  13. The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.
    Mol Cell. 2001 Oct;8(4):829-39 PMID: 11684018
  14. Modular phosphoinositide-binding domains--their role in signalling and membrane trafficking.
    Curr Biol. 2001 Oct 30;11(21):R882-93 PMID: 11696348
  15. All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate.
    J Biol Chem. 2001 Nov 23;276(47):44179-84 PMID: 11557775
  16. Recognizing phosphatidylinositol 3-phosphate.
    Cell. 2001 Nov 30;107(5):559-62 PMID: 11733055
  17. Curvature of clathrin-coated pits driven by epsin.
    Nature. 2002 Sep 26;419(6905):361-6 PMID: 12353027
  18. Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction.
    EMBO J. 2002 Oct 1;21(19):5057-68 PMID: 12356722
  19. Plasma membrane microdomains.
    Curr Opin Cell Biol. 2002 Aug;14(4):483-7 PMID: 12383800
  20. The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation.
    J Biol Chem. 2002 Dec 13;277(50):48730-6 PMID: 12198132
  21. Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.
    Curr Biol. 2003 Mar 18;13(6):504-9 PMID: 12646134
  22. Phosphoinositide recognition domains.
    Traffic. 2003 Apr;4(4):201-13 PMID: 12694559
  23. Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.
    EMBO J. 2003 Aug 15;22(16):4178-89 PMID: 12912916
  24. Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi.
    Cell. 2003 Aug 8;114(3):299-310 PMID: 12914695
  25. Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.
    J Biol Chem. 2003 Sep 5;278(36):33617-20 PMID: 12857747
  26. Ent3p Is a PtdIns(3,5)P2 effector required for protein sorting to the multivesicular body.
    Dev Cell. 2003 Sep;5(3):499-511 PMID: 12967568
  27. Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
    J Biol Chem. 2003 Sep 19;278(38):36572-81 PMID: 12826668
  28. Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.
    J Biol Chem. 2003 Oct 3;278(40):38786-95 PMID: 12878588
  29. Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis.
    Nat Cell Biol. 2003 Nov;5(11):1016-22 PMID: 14528311
  30. Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes.
    Histochem Cell Biol. 2003 Dec;120(6):445-53 PMID: 14618335
  31. Multivalent mechanism of membrane insertion by the FYVE domain.
    J Biol Chem. 2004 Jan 23;279(4):3050-7 PMID: 14578346
  32. Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy.
    Biochem J. 2004 Feb 1;377(Pt 3):653-63 PMID: 14604433
  33. BAR domains as sensors of membrane curvature: the amphiphysin BAR structure.
    Science. 2004 Jan 23;303(5657):495-9 PMID: 14645856
  34. Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains.
    Mol Cell. 2004 Mar 12;13(5):677-88 PMID: 15023338
  35. Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins.
    Biophys J. 2004 Apr;86(4):2188-207 PMID: 15041659
  36. Adaptable adaptors for coated vesicles.
    Trends Cell Biol. 2004 Apr;14(4):167-74 PMID: 15066634
  37. Inositol lipids: to PHix or not to PHix?
    Curr Biol. 2004 Apr 20;14(8):R308-10 PMID: 15084300
  38. The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate.
    J Biol Chem. 2004 Apr 23;279(17):17101-10 PMID: 14766750
  39. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.
    Nat Cell Biol. 2004 May;6(5):393-404 PMID: 15107860
  40. Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.
    EMBO J. 2004 May 5;23(9):1922-33 PMID: 15103325
  41. PI-loting membrane traffic.
    Nat Cell Biol. 2004 Jun;6(6):487-92 PMID: 15170460
  42. Ent5p is required with Ent3p and Vps27p for ubiquitin-dependent protein sorting into the multivesicular body.
    Mol Biol Cell. 2004 Jul;15(7):3031-41 PMID: 15107463
  43. Phosphoinositides in constitutive membrane traffic.
    Physiol Rev. 2004 Jul;84(3):699-730 PMID: 15269334
  44. Chemotaxis: signalling the way forward.
    Nat Rev Mol Cell Biol. 2004 Aug;5(8):626-34 PMID: 15366706
  45. Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes.
    Mol Cell Biol. 2004 Oct;24(20):9102-23 PMID: 15456883
  46. Membrane domains.
    Annu Rev Cell Dev Biol. 2004;20:839-66 PMID: 15473862
  47. Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p.
    J Biol Chem. 2004 Oct 22;279(43):44683-9 PMID: 15271978
  48. Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.
    Curr Biol. 2004 Oct 26;14(20):1791-800 PMID: 15498486
  49. The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein.
    Cell. 1993 Jun 4;73(5):999-1005 PMID: 8500185
  50. Biochemical dissection of AP-1 recruitment onto Golgi membranes.
    J Cell Biol. 1993 Nov;123(3):561-73 PMID: 8227126
  51. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function.
    Nature. 1998 Mar 12;392(6672):193-7 PMID: 9515966
  52. Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells.
    Curr Biol. 1998 Mar 12;8(6):343-6 PMID: 9512420
  53. The pleckstrin homology domains of dynamin isoforms require oligomerization for high affinity phosphoinositide binding.
    J Biol Chem. 1998 Oct 16;273(42):27725-33 PMID: 9765310
  54. Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation.
    J Cell Sci. 2004 Dec 15;117(Pt 26):6413-24 PMID: 15561769
  55. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density.
    Mol Cell. 2005 Jan 21;17(2):181-91 PMID: 15664188
  56. Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain.
    Nature. 2005 Mar 3;434(7029):99-104 PMID: 15744307
  57. Determinants of the endosomal localization of sorting nexin 1.
    Mol Biol Cell. 2005 Apr;16(4):2049-57 PMID: 15673616
  58. PI(4,5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility.
    J Cell Biol. 2005 Apr 11;169(1):151-65 PMID: 15809307
  59. The activation of exocytotic sites by the formation of phosphatidylinositol 4,5-bisphosphate microdomains at syntaxin clusters.
    J Biol Chem. 2005 Apr 29;280(17):17346-52 PMID: 15741173
  60. Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions.
    J Cell Sci. 2005 May 15;118(Pt 10):2093-104 PMID: 15890985
  61. Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.
    Mol Cell. 2005 May 27;18(5):519-31 PMID: 15916959
  62. PIP2 signaling in lipid domains: a critical re-evaluation.
    EMBO J. 2005 May 4;24(9):1664-73 PMID: 15861130
  63. Phosphatidylinositol-3-OH kinases are Rab5 effectors.
    Nat Cell Biol. 1999 Aug;1(4):249-52 PMID: 10559924
  64. Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation.
    Cell. 1999 Nov 24;99(5):521-32 PMID: 10589680
  65. The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization.
    J Biol Chem. 2000 Feb 4;275(5):3699-705 PMID: 10652369
  66. GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism.
    J Cell Biol. 2000 Jun 26;149(7):1455-72 PMID: 10871285
  67. How accurately can we image inositol lipids in living cells?
    Trends Pharmacol Sci. 2000 Jul;21(7):238-41 PMID: 10871889
  68. Dynamics of phosphatidylinositol 4,5-bisphosphate in actin-rich structures.
    Curr Biol. 2000 Jun 15;10(12):743-6 PMID: 10873804
  69. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells.
    EMBO J. 2000 Sep 1;19(17):4577-88 PMID: 10970851
  70. Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains.
    Mol Cell. 2000 Aug;6(2):385-94 PMID: 10983985
  71. Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity.
    EMBO J. 2000 Oct 16;19(20):5440-9 PMID: 11032811
  72. Rab proteins as membrane organizers.
    Nat Rev Mol Cell Biol. 2001 Feb;2(2):107-17 PMID: 11252952
Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
0962-8924
DOI
10.1016/j.tcb.2005.08.005
Published
2005-10-00
Pages
540-7
Language
English
Region
England
NLM ID
9200566
PMCID
PMC1904488
Subset
IM
Grants
Wellcome Trust · United Kingdom
Wellcome Trust · 076126 · United Kingdom
External Links
PubMed source DOI: 10.1016/j.tcb.2005.08.005 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2