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PMID: 19696797 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Review

Pathways and mechanisms of endocytic recycling.

Nature reviews. Molecular cell biology ·Vol. 10 ·No. 9 ·2009-09-00 ·Pages 597-608

Grant BD, Donaldson JG

Abstract

Endocytic recycling is coordinated with endocytic uptake to control the composition of the plasma membrane. Although much of our understanding of endocytic recycling has come from studies on the transferrin receptor, a protein internalized through clathrin-dependent endocytosis, increased interest in clathrin-independent endocytosis has led to the discovery of new endocytic recycling systems. Recent insights into the regulatory mechanisms that control endocytic recycling have focused on recycling through tubular carriers and the return to the cell surface of cargoes that enter cells through clathrin-independent mechanisms. Recent work emphasizes the importance of regulated recycling in processes as diverse as cytokinesis, cell adhesion, morphogenesis, cell fusion, learning and memory.

MeSH Terms
Animals Clathrin/physiology Endocytosis/physiology Humans Receptors, Transferrin/metabolism Signal Transduction
Chemicals
Clathrin Receptors, Transferrin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Grant Barth D
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA. grant@biology.rutgers.edu
Donaldson Julie G
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2755
Email
grant@biology.rutgers.edu
Published
2009-09-00
Pages
597-608
Language
English
Region
England
NLM ID
100962782
PMCID
PMC3038567
Subset
IM
Grants
NIGMS NIH HHS · R01 GM067237 · United States
NIGMS NIH HHS · R01 GM067237-07 · United States
Intramural NIH HHS · United States
External Links
PubMed source DOI: 10.1038/nrm2755 PMC Full Text View journal details
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