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PMID: 18801062 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Mechanisms of EHD/RME-1 protein function in endocytic transport.

Traffic (Copenhagen, Denmark) ·Vol. 9 ·No. 12 ·2008-12-00 ·Pages 2043-52

Grant BD, Caplan S

Abstract

The evolutionarily conserved Eps15 homology domain (EHD)/receptor-mediated endocytosis (RME)-1 family of C-terminal EH domain proteins has recently come under intense scrutiny because of its importance in intracellular membrane transport, especially with regard to the recycling of receptors from endosomes to the plasma membrane. Recent studies have shed new light on the mode by which these adenosine triphosphatases function on endosomal membranes in mammals and Caenorhabditis elegans. This review highlights our current understanding of the physiological roles of these proteins in vivo, discussing conserved features as well as emerging functional differences between individual mammalian paralogs. In addition, these findings are discussed in light of the identification of novel EHD/RME-1 protein and lipid interactions and new structural data for proteins in this family, indicating intriguing similarities to the Dynamin superfamily of large guanosine triphosphatases.

MeSH Terms
Animals Biological Transport Endocytosis Humans Lipid Metabolism Nucleotides/metabolism Protein Binding Vesicular Transport Proteins/chemistry,genetics,metabolism
Chemicals
Nucleotides Vesicular Transport Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Grant Barth D
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. grant@biology.rutgers.edu
Caplan Steve
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Article Info
Journal
Traffic (Copenhagen, Denmark)
Abbr.
Traffic
ISSN
1600-0854
DOI
10.1111/j.1600-0854.2008.00834.x
Email
grant@biology.rutgers.edu
Published
2008-12-00
Epub
2008-00-14
Pages
2043-52
Language
English
Region
England
NLM ID
100939340
PMCID
PMC2766864
Subset
IM
Grants
NIGMS NIH HHS · GM067237 · United States
NIGMS NIH HHS · R01 GM074876-04 · United States
NIGMS NIH HHS · R01 GM067237-06 · United States
NIGMS NIH HHS · R01 GM067237 · United States
NIGMS NIH HHS · R01 GM074876 · United States
NIGMS NIH HHS · GM074876 · United States
External Links
PubMed source DOI: 10.1111/j.1600-0854.2008.00834.x PMC Full Text View journal details
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