Lipid traffic: Osh4p makes an unexpected exchange.

The Journal of cell biology ·Vol. 195 ·No. 6 ·2011-12-12 ·Pages 927-9

Levine TP

Abstract

A new study in this issue (De Saint-Jean et al. 2011. J. Cell Biol. http://dx.doi.org/jcb.201104062) reveals that the sterol transfer protein Osh4p can also transport the signaling phospholipid phosphatidylinositol 4-phosphate (PI(4)P), which binds to the same site in Osh4p as sterol. This finding helps explain some previously published studies and also indicates that lipid/sterol exchange could contribute to establishing a sterol gradient in cells.

MeSH Terms

Ergosterol/analogs & derivatives,chemistry Lipid Bilayers/chemistry Membrane Proteins/chemistry Phosphatidylinositol Phosphates/chemistry Receptors, Steroid/chemistry Saccharomyces cerevisiae Proteins/chemistry

Chemicals

KES1 protein, S cerevisiae Lipid Bilayers Membrane Proteins Phosphatidylinositol Phosphates Receptors, Steroid Saccharomyces cerevisiae Proteins phosphatidylinositol 4-phosphate dehydroergosterol Ergosterol

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Levine Tim P

Institute of Ophthalmology, University College London, London EC1V 9EL, England, UK. tim.levine@ucl.ac.uk

References (14)

14 references, click to expand

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Traffic. 2011 Nov;12(11):1521-36 PMID: 21819498
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Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers.
J Cell Biol. 2011 Dec 12;195(6):965-78 PMID: 22162133
A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes.
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Article Info

Journal

The Journal of cell biology

Abbr.

J Cell Biol

ISSN

1540-8140

DOI

10.1083/jcb.201111074

tim.levine@ucl.ac.uk

Published

2011-12-12

Pages

927-9

Language

English

Region

United States

NLM ID

0375356

PMCID

PMC3241729

Subset

Corrections

CommentOn

PMID: 22162133

External Links

PubMed source DOI: 10.1083/jcb.201111074 PMC Full Text View journal details

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