mTOR Signaling.

Cold Spring Harbor perspectives in biology ·Vol. 4 ·No. 2 ·2012-02-01

Laplante M, Sabatini DM

Abstract

暂无摘要

MeSH Terms

Humans Signal Transduction TOR Serine-Threonine Kinases/metabolism

Chemicals

MTOR protein, human TOR Serine-Threonine Kinases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Laplante Mathieu

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ), Université Laval, Québec, Canada. mathieu.laplante@criucpq.ulaval.ca

Sabatini David M

References (10)

10 references, click to expand

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.
Cell. 1993 May 7;73(3):585-96 PMID: 8387896
An emerging role of mTOR in lipid biosynthesis.
Curr Biol. 2009 Dec 1;19(22):R1046-52 PMID: 19948145
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.
J Antibiot (Tokyo). 1975 Oct;28(10):721-6 PMID: 1102508
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.
Cell. 1994 Jul 15;78(1):35-43 PMID: 7518356
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.
Science. 1991 Aug 23;253(5022):905-9 PMID: 1715094
A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
Nature. 1994 Jun 30;369(6483):756-8 PMID: 8008069
mTOR: from growth signal integration to cancer, diabetes and ageing.
Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35 PMID: 21157483
mTOR signaling at a glance.
J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94 PMID: 19812304
Molecular mechanisms of mTOR-mediated translational control.
Nat Rev Mol Cell Biol. 2009 May;10(5):307-18 PMID: 19339977
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells.
J Biol Chem. 1995 Jan 13;270(2):815-22 PMID: 7822316

Article Info

Journal

Cold Spring Harbor perspectives in biology

Abbr.

Cold Spring Harb Perspect Biol

ISSN

1943-0264

DOI

10.1101/cshperspect.a011593

mathieu.laplante@criucpq.ulaval.ca

Published

2012-02-01

Epub

2012-00-01

Language

English

Region

United States

NLM ID

101513680

PMCID

PMC3281571

Subset

Grants

NIAID NIH HHS · R01 AI047389 · United States

NCI NIH HHS · R01 CA103866 · United States

NCI NIH HHS · R01 CA129105 · United States

NIAID NIH HHS · R37 AI047389 · United States

External Links

PubMed source DOI: 10.1101/cshperspect.a011593 PMC Full Text View journal details

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