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PMID: 19948145 Published · ppublish English Journal Article Review

An emerging role of mTOR in lipid biosynthesis.

Current biology : CB ·Vol. 19 ·No. 22 ·2009-12-01 ·Pages R1046-52

Laplante M, Sabatini DM

Abstract

Lipid biosynthesis is essential for the maintenance of cellular homeostasis. The lipids produced by cells (glycerolipids, fatty acids, phospholipids, cholesterol, and sphingolipids) are used as an energy source/reserve, as building blocks for membrane biosynthesis, as precursor molecules for the synthesis of various cellular products, and as signaling molecules. Defects in lipid synthesis or processing contribute to the development of many diseases, including obesity, insulin resistance, type 2 diabetes, non-alcoholic fatty liver disease, and cancer. Studies published over the last few years have shown that the target of rapamycin (TOR), a conserved serine/threonine kinase with an important role in regulating cell growth, controls lipid biosynthesis through various mechanisms. Here, we review these findings and briefly discuss their potential relevance for human health and disease.

MeSH Terms
Humans Intracellular Signaling Peptides and Proteins/physiology Lipids/biosynthesis Nuclear Proteins/physiology PPAR gamma/physiology Phosphatidate Phosphatase Protein Serine-Threonine Kinases/physiology Sterol Regulatory Element Binding Protein 1/physiology TOR Serine-Threonine Kinases
Chemicals
Intracellular Signaling Peptides and Proteins Lipids Nuclear Proteins PPAR gamma SREBF1 protein, human Sterol Regulatory Element Binding Protein 1 MTOR protein, human Protein Serine-Threonine Kinases TOR Serine-Threonine Kinases LPIN1 protein, human Phosphatidate Phosphatase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Laplante Mathieu
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Sabatini David M
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Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
1879-0445
DOI
10.1016/j.cub.2009.09.058
Published
2009-12-01
Pages
R1046-52
Language
English
Region
England
NLM ID
9107782
PMCID
PMC3390254
Subset
IM
Grants
NIAID NIH HHS · R01 AI047389 · United States
NCI NIH HHS · R01 CA103866 · United States
NCI NIH HHS · R01 CA129105 · United States
External Links
PubMed source DOI: 10.1016/j.cub.2009.09.058 PMC Full Text View journal details
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