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PMID: 17041137 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Emerging respiratory viruses: challenges and vaccine strategies.

Clinical microbiology reviews ·Vol. 19 ·No. 4 ·2006-10-00 ·Pages 614-36

Gillim-Ross L, Subbarao K

Abstract

The current threat of avian influenza to the human population, the potential for the reemergence of severe acute respiratory syndrome (SARS)-associated coronavirus, and the identification of multiple novel respiratory viruses underline the necessity for the development of therapeutic and preventive strategies to combat viral infection. Vaccine development is a key component in the prevention of widespread viral infection and in the reduction of morbidity and mortality associated with many viral infections. In this review we describe the different approaches currently being evaluated in the development of vaccines against SARS-associated coronavirus and avian influenza viruses and also highlight the many obstacles encountered in the development of these vaccines. Lessons learned from current vaccine studies, coupled with our increasing knowledge of the host and viral factors involved in viral pathogenesis, will help to increase the speed with which efficacious vaccines targeting newly emerging viral pathogens can be developed.

MeSH Terms
Animals Humans Influenza A virus/genetics,physiology Influenza, Human/genetics,transmission Metapneumovirus/isolation & purification Paramyxoviridae Infections/epidemiology,prevention & control,virology Respiratory Tract Infections/epidemiology,prevention & control,virology SARS Virus/isolation & purification Viral Vaccines/administration & dosage,immunology Virus Diseases/epidemiology,prevention & control,transmission,virology Zoonoses/virology
Chemicals
Viral Vaccines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gillim-Ross Laura
Laboratory of Infectious Diseases, National Insitute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Subbarao Kanta
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.00005-06
Published
2006-10-00
Pages
614-36
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC1592697
Subset
IM
Grants
Intramural NIH HHS · United States
External Links
PubMed source DOI: 10.1128/CMR.00005-06 PMC Full Text View journal details
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