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PMID: 10920197 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 97 ·No. 17 ·2000-08-15 ·Pages 9654-8

Lin YP, Shaw M, Gregory V, Cameron K, Lim W, Klimov A, Subbarao K, Guan Y, Krauss S, Shortridge K, Webster R, Cox N, Hay A

Abstract

In 1997, 18 cases of influenza in Hong Kong (bird flu) caused by a novel H5N1 (chicken) virus resulted in the deaths of six individuals and once again raised the specter of a potentially devastating influenza pandemic. Slaughter of the poultry in the live bird markets removed the source of infection and no further human cases of H5N1 infection have occurred. In March 1999, however, a new pandemic threat appeared when influenza A H9N2 viruses infected two children in Hong Kong. These two virus isolates are similar to an H9N2 virus isolated from a quail in Hong Kong in late 1997. Although differing in their surface hemagglutinin and neuraminidase components, a notable feature of these H9N2 viruses is that the six genes encoding the internal components of the virus are similar to those of the 1997 H5N1 human and avian isolates. This common feature emphasizes the apparent propensity of avian viruses with this genetic complement to infect humans and highlights the potential for the emergence of a novel human pathogen.

MeSH Terms
Animals Antigens, Viral/chemistry,genetics,immunology Binding Sites Bird Diseases/epidemiology,transmission Child, Preschool Conserved Sequence/genetics Female Genes, Viral/genetics Genetic Variation/genetics Hemagglutinins, Viral/chemistry,genetics,immunology Hong Kong/epidemiology Humans Infant Influenza A Virus, H5N1 Subtype Influenza A Virus, H9N2 Subtype Influenza A virus/chemistry,classification,genetics,immunology Influenza, Human/epidemiology,transmission Molecular Sequence Data Neuraminidase/chemistry,genetics,immunology Phylogeny Quail/virology Species Specificity
Chemicals
Antigens, Viral Hemagglutinins, Viral Neuraminidase
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Lin Y P
Division of Virology, National Institute for Medical Research, Mill Hill, London, United Kingdom. Dise. lyipu@nimr.mrc.ac.uk
Shaw M
Gregory V
Cameron K
Lim W
Klimov A
Subbarao K
Guan Y
Krauss S
Shortridge K
Webster R
Cox N
Hay A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.160270697
Email
lyipu@nimr.mrc.ac.uk
Published
2000-08-15
Pages
9654-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC16920
Subset
IM
Grants
NIAID NIH HHS · AI9537 · United States
NCI NIH HHS · CA21765 · United States
NIAID NIH HHS · F32 AI009537 · United States
NCI NIH HHS · P30 CA021765 · United States
NIAID NIH HHS · AI29680 · United States
Databases
GENBANK
AJ278646, AJ278647, AJ278648, AJ278649, AJ289871, AJ289872, AJ289873, AJ289874, AJ404626, AJ404627, AJ404628, AJ404629, AJ404630, AJ404631, AJ404632, AJ404633, AJ404634, AJ404635, AJ404636, AJ404637, AJ404735, AJ404736
External Links
PubMed source DOI: 10.1073/pnas.160270697 PMC Full Text View journal details
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