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PMID: 15827197 Published · ppublish English Comparative Study Journal Article

Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans.

Journal of virology ·Vol. 79 ·No. 9 ·2005-05-00 ·Pages 5833-8

Roberts A, Paddock C, Vogel L, Butler E, Zaki S, Subbarao K

Abstract

Advanced age has repeatedly been identified as an independent correlate of adverse outcome and a predictor of mortality in cases of severe acute respiratory syndrome (SARS). SARS-associated mortality may exceed 50% for persons aged 60 years or older. Heightened susceptibility of the elderly to severe SARS and the ability of SARS coronavirus to replicate in mice led us to examine whether aged mice might be susceptible to disease. We report here that viral replication in aged mice was associated with clinical illness and pneumonia, demonstrating an age-related susceptibility to SARS disease in animals that parallels the human experience.

MeSH Terms
Age Factors Animals Disease Models, Animal Disease Progression Disease Susceptibility Mice Mice, Inbred BALB C Pneumonia/pathology SARS Virus Severe Acute Respiratory Syndrome/diagnosis,virology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Roberts Anjeanette
LID, NIAID, NIH, 50 South Dr., Room 6351, MSC 8007, Bethesda, MD 20892, USA. ajroberts@niaid.nih.gov
Paddock Christopher
Vogel Leatrice
Butler Emily
Zaki Sherif
Subbarao Kanta
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.79.9.5833-5838.2005
Email
ajroberts@niaid.nih.gov
Published
2005-05-00
Pages
5833-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC1082763
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.79.9.5833-5838.2005 PMC Full Text View journal details
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