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PMID: 15681402 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Identification of a novel coronavirus in bats.

Journal of virology ·Vol. 79 ·No. 4 ·2005-02-00 ·Pages 2001-9

Poon LL, Chu DK, Chan KH, Wong OK, Ellis TM, Leung YH, Lau SK, Woo PC, Suen KY, Yuen KY, Guan Y, Peiris JS

Abstract

Exotic wildlife can act as reservoirs of diseases that are endemic in the area or can be the source of new emerging diseases through interspecies transmission. The recent emergence of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) highlights the importance of virus surveillance in wild animals. Here, we report the identification of a novel bat coronavirus through surveillance of coronaviruses in wildlife. Analyses of the RNA sequence from the ORF1b and S-gene regions indicated that the virus is a group 1 coronavirus. The virus was detected in fecal and respiratory samples from three bat species (Miniopterus spp.). In particular, 63% (12 of 19) of fecal samples from Miniopterus pusillus were positive for the virus. These findings suggest that this virus might be commonly circulating in M. pusillus in Hong Kong.

MeSH Terms
Amino Acid Sequence Animals Chiroptera Coronavirus/classification,genetics,isolation & purification Genome, Viral Molecular Sequence Data Phylogeny RNA, Viral/analysis,genetics Reverse Transcriptase Polymerase Chain Reaction
Chemicals
RNA, Viral
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Poon L L M
Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, Special Administrative Region, People's Republic of China. llmpoon@hkucc.hku.hk
Chu D K W
Chan K H
Wong O K
Ellis T M
Leung Y H C
Lau S K P
Woo P C Y
Suen K Y
Yuen K Y
Guan Y
Peiris J S M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.79.4.2001-2009.2005
Email
llmpoon@hkucc.hku.hk
Published
2005-02-00
Pages
2001-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC546586
Subset
IM
Grants
NIAID NIH HHS · N01AI95357 · United States
Databases
GENBANK
AY864196, AY864197, AY864198
External Links
PubMed source DOI: 10.1128/JVI.79.4.2001-2009.2005 PMC Full Text View journal details
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