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PMID: 9557750 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus.

Journal of virology ·Vol. 72 ·No. 5 ·1998-05-00 ·Pages 4508-14

Herrewegh AA, Smeenk I, Horzinek MC, Rottier PJ, de Groot RJ

Abstract

Recent evidence suggests that the type II feline coronavirus (FCoV) strains 79-1146 and 79-1683 have arisen from a homologous RNA recombination event between FCoV type I and canine coronavirus (CCV). In both cases, the template switch apparently took place between the S and M genes, giving rise to recombinant viruses which encode a CCV-like S protein and the M, N, 7a, and 7b proteins of FCoV type I (K. Motowaka, T. Hohdatsu, H. Hashimoto, and H. Koyama, Microbiol. Immunol. 40:425-433, 1996; H. Vennema, A. Poland, K. Floyd Hawkins, and N. C. Pedersen, Feline Pract. 23:40-44, 1995). In the present study, we have looked for additional FCoV-CCV recombination sites. Four regions in the pol gene were selected for comparative sequence analysis of the type II FCoV strains 79-1683 and 79-1146, the type I FCoV strains TN406 and UCD1, the CCV strain K378, and the TGEV strain Purdue. Our data show that the type II FCoVs have arisen from double recombination events: additional crossover sites were mapped in the ORF1ab frameshifting region of strain 79-1683 and in the 5' half of ORF1b of strain 79-1146.

MeSH Terms
Animals Base Sequence Cats Cell Line Coronavirus/genetics Coronavirus, Canine/genetics DNA, Viral Dogs Molecular Sequence Data Recombination, Genetic
Chemicals
DNA, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Herrewegh A A
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Smeenk I
Horzinek M C
Rottier P J
de Groot R J
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.72.5.4508-4514.1998
Published
1998-05-00
Pages
4508-14
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC109693
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.72.5.4508-4514.1998 PMC Full Text View journal details
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